ksreekanth
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India,
2020-05-20 13:22

Posting: # 21453
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 Processed Sample Stability [Bioanalytics]

Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.
Any further PS Stability experiment need to be proved at refrigerator (4°C) condition. Since auto-sampler condition were maintained at 10°C during the Processed Sample analysis.


Edit: Category changed; see also this post #1; please follow the Forum’s Policy[Helmut]
Helmut
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Vienna, Austria,
2020-05-20 16:29

@ ksreekanth
Posting: # 21454
Views: 165
 

 Processed Sample Stability

Hi ksreekanth,

» Processed Sample (PS) Stability proved at 10°C (In Auto-sampler), Can we analyze the processed Samples which were stored in refrigerator (4°C) for which stability was not established at refrigerator (4°C) condition.

What are your thoughts – do you remember the [image] Arrhenius equation? However, in the strict sense (!) autosampler stability  processed sample stability.

This reminds me on heated discussions at the Crystal City III workshop along these lines:

“We have validated long-term stability at –20℃.
Can we store samples at –70℃ without re-validation?”

Amazingly some answered “Yes!”
Was – and is – beyond my intellectual reach. See also Ohlbe’s post.

Cheers,
Helmut Schütz
[image]

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