BE-proff ● 2018-12-24 18:58 (1920 d 15:57 ago) Posting: # 19714 Views: 2,820 |
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Hi All, let's say I want to conduct a BE study using RSABE (EMA). From previous studies I have both AUCs and Cmax with their GMR and CVintra. Which parameter is better for sample size calculation - AUC or Cmax? |
mittyri ★★ Russia, 2018-12-24 22:33 (1920 d 12:22 ago) @ BE-proff Posting: # 19715 Views: 2,216 |
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Hi BE-proff, ❝ From previous studies I have both AUCs and Cmax with their GMR and CVintra. ❝ Which parameter is better for sample size calculation - AUC or Cmax? You need to take into account both. Remember this one? The leading metric depends on CV and GMR. — Kind regards, Mittyri |