ElMaestro
★★★

Belgium?,
2018-08-15 11:02
(774 d 20:21 ago)

Posting: # 19169
Views: 2,017
 

 Spelling out FDA's pop BE model [General Sta­tis­tics]

Dear all,

I am trying to spell out the underlying model of FDA's pop BE analysis used for in vitro comparison of signle actuator content and more. A link is here.

The players are:

The formulations (F, two levels)
The stages (S, three levels in FDA's example, but may be anything from one upwards)
The cans ("Cans in batch", C, at least ten levels)
The batches ("batch within formulation", B, at least three levels)

I was initially thinking
Y=F+S+C+B+ek where ek is N(0, MSWk), and where Y is the in vitro metric we are sampling, like SAC, and where we's consider C, possibly B and S random (?).

But since MSWk comes from sampling across stages, I am inclined to work without S, so
a. Y=F+C+B+ek,
where C and possibly B are random. When there is only a single sampled stage I guess this would then be
b. Y=F+B+ek where ek is then N(0, MSBk)

What's your opinion on a. and b.?
How would you formulate the models yourself?

I could be wrong, but...

Best regards,
ElMaestro

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.
nobody
nothing

2018-08-17 09:18
(772 d 22:05 ago)

@ ElMaestro
Posting: # 19170
Views: 1,601
 

 Spelling out FDA's pop BE model

...maybe a post to the NONMEM users would be an option?

[email protected]

;-)

Kindest regards, nobody
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