Bioequivalence and Bioavailability Forum 00:20 CET

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Melkor
Junior

Greece,
2018-06-03 11:02

Posting: # 18843
Views: 510
 

 Rapid dissolution paradox [Dissolution / BCS / IVIVC]

Greetings!

I have been facing a paradox with a specific solid dosage formula with rapid dissolution rate. When conducting the dissolution test at three conventional pH the %release of the test product at 4.5 pH lowers upon reaching the max %release in 5 mins and then reaches a plateau. This does not happen for the RLD at the same pH and the performance for both product at all remaining pH is similar.

I have faced this before with rapid dissolution products but i would really like to have a scientific explanation on this.

Any ideas?

Thank you


Edit: Category changed; see also this post #1. [Helmut]
Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
18,923 posts in 4,039 threads, 1,284 registered users;
online 6 (0 registered, 6 guests [including 5 identified bots]).

If you think it’s simple,
then you have misunderstood the problem.    Bjarne Stroustrup

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed