Posting: # 18683
I had a question about the numerical deconvolution method. I am using the IVIVC toolkit for this. Is it possible to have a non-zero value for the input rate at the zero time-point? If yes, when does this happen and how do you interpret it?
Posting: # 18686
Are you aware there is a forum dedicated to Certara's Phoenix IVIVC software, if you are using this then I suggest you *follow* this forum as you may find several tips and tricks of interest to you.
Also I'm not sure if yours is a 'trick' question;
" I am using the IVIVC toolkit for this. Is it possible to have a non-zero value for the input rate at the zero time-point?"
So my question to you is do you have a profile that exhibits this behaviour and if so what happened? Since it's Monday and I'm procrastinating on something else, I just tried this in a project and I see it triggers the following error message;
So moving to the second part
"If yes, when does this happen and how do you interpret it? "
Well I guess you have to consider what this means, you are trying to deconvolve a profile to better understand the absorption process; it's not considered probable that from extravascular dosing you would instantly see drug in the blood stream so here are a few possibilites to consider.
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