Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-07-23 17:37 CEST (UTC+2h)
Deepti Maru
Junior

India,
2018-04-07 17:48

Posting: # 18653
Views: 810
 

 Selection of linearity range in bioanalysis [Bioanalytics]

What is the need to go down upto 5 or 7 or 10 half lives while developing a bioanalytical method?


Edit: Please follow the Forum’s Policy[Helmut]
cakhatri
Regular

India,
2018-05-03 10:35

@ Deepti Maru
Posting: # 18752
Views: 342
 

 Selection of linearity range in bioanalysis

Dear Deepti Maru,

The need to have lower LOQ (5,7 or 10 half lives) should be correlated to the number of half lives upto which sample is collected as per protocol or likely to be collected

If the sampling is carried out upto 6 half lives - For a drug with 12 Hr Half life, the last sampling point will be 72 hours. Under such scenario, LOQ can be upto 7 half lives

This will ensure possibility of minimal BLQ samples in absorption / elimination phase.

It is necessary to have a reproducible LOQ

Regards
Chirag
Back to the forum Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
18,547 posts in 3,941 threads, 1,190 registered users;
online 11 (0 registered, 11 guests [including 10 identified bots]).

[The] impatience with ambiguity can be criticized in the phrase:
absence of evidence is not evidence of absence.    Carl Sagan

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed