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Back to the forum  Query: 2018-02-21 12:12 CET (UTC+1h)
 
Yura
Regular

Belarus,
2018-01-23 15:02

Posting: # 18269
Views: 979
 

 Power R WinNonLin [Power / Sample Size]

Hi everybody

From the research 2x2x2 (34 - balanced) for power estimation the following results are taken: β=0.20, α=0.05, CV = 0.32, PE = 0.92

FARTSSIE17: 55%
R: 55%
WinNonLin: Power_80_20: 89%
Why is this happening?
Regards
d_labes
Hero

Berlin, Germany,
2018-01-23 15:25

@ Yura
Posting: # 18271
Views: 760
 

 Power R WinNonLin

Dear Yura

have a look at this thread from the year 2011.

And tell us which version of WinNonlin you used for your calculations.
AFAIK Phoenix had corrected this nonsense power calculations later on.

Regards,

Detlew
Helmut
Hero
Homepage
Vienna, Austria,
2018-01-23 16:05

@ d_labes
Posting: # 18274
Views: 747
 

 Power_TOST in PHX/WNL 6.4+

Dear Detlew & Yura

» And tell us which version of WinNonlin you used for your calculations.
» AFAIK Phoenix had corrected this nonsense power calculations later on.

The additional result Power_TOST was introduced in Phoenix WinNonlin v6.4 (2014). During development it was cross-validated against power.TOST(..., method="nct"). ;-)
Power_80_20 (for the FDA’s 80/20-rule) is still there for backwards compatibility. Don’t use it.

[image]Regards,
Helmut Schütz 
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
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d_labes
Hero

Berlin, Germany,
2018-01-23 16:54

@ Helmut
Posting: # 18275
Views: 735
 

 Power_TOST in PHX/WNL 6.4+

Dear Helmut!

» The additional result Power_TOST was introduced in Phoenix WinNonlin v6.4 (2014). During development it was cross-validated against power.TOST(..., method="nct"). ;-)

Funny :cool:.

Regards,

Detlew
Helmut
Hero
Homepage
Vienna, Austria,
2018-01-23 17:25

@ d_labes
Posting: # 18276
Views: 752
 

 Power_TOST in PHX/WNL 6.4+

Dear Detlew!

» » […] Power_TOST was introduced in Phoenix WinNonlin v6.4 (2014). […] it was cross-validated against power.TOST(..., method="nct"). ;-)
»
» Funny :cool:.

I bombarded Pharsight for years asking for an update. I was a beta-tester of PHX v6.0–6.4. Guess who suggested which software to compare to. :-D

[image]Regards,
Helmut Schütz 
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
Yura
Regular

Belarus,
2018-01-23 21:55

@ Helmut
Posting: # 18284
Views: 709
 

 Power_TOST in PHX/WNL 6.4+

Hi Detlew & Helmut
» Power_80_20 (for the FDA’s 80/20-rule) is still there for backwards compatibility. Don’t use it.

Thanks for the advice
WNL's Power do not use

Regards
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