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Norah ★ Tunisia, 2018-01-22 15:50 (2283 d 00:20 ago) Posting: # 18248 Views: 4,470 |
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Hello do you know if we can enroll light smokers volunteers in a BE study evaluating the Diclofenac LP? thanks Edit: Category changed; see also this post #1. [Helmut] |
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Relaxation ★ Germany, 2018-01-22 19:26 (2282 d 20:44 ago) @ Norah Posting: # 18251 Views: 3,843 |
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❝ do you know if we can enroll light smokers volunteers in a BE study evaluating the Diclofenac LP? Hello Norah. I am sorry, but I have to leave now and can only kickstart the discussion (maybe) with a quite general statement: You could in principle and there are some arguments for that. But you may have an easier life, if it is not necessary. I would be interested in your thinking so far and hopefully will find some time to re-join the thread later. Best regards, Relax  Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] |
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Helmut ★★★   Vienna, Austria, 2018-01-22 19:43 (2282 d 20:27 ago) @ Relaxation Posting: # 18252 Views: 3,846 |
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Hi Relaxation, I agree. In general I would not worry too much about including mild to moderate smokers unless a drug is mainly (!) metabolized by CYP1A1. @Norah: Check the literature whether diclofenac is a substrate for CYP1A1 (I don’t think so). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Norah ★ Tunisia, 2018-01-23 09:11 (2282 d 06:59 ago) @ Helmut Posting: # 18257 Views: 3,797 |
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thank u Helmut :) |
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Norah ★ Tunisia, 2018-01-23 09:11 (2282 d 06:59 ago) (edited by Ohlbe on 2018-01-23 11:12) @ Relaxation Posting: # 18256 Views: 3,804 |
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thank u relaxation :) diclofenac is a substrate of cytochrome P450 2C9 / tobacco is an inducer of cytochromes P450 1A1, 1A2 and 2E1 therefore no effect of tobacco on the metabolism of diclofenac. Edit: two posts merged. You can edit your messages during 24h, which is preferred over answering your own message [Ohlbe] |
Ing. Helmut Schütz