Bioequivalence and Bioavailability Forum

youivab ☆ Korea, 2017-12-27 07:20 (2304 d 17:56 ago) (edited by youivab on 2017-12-28 01:38) Posting: # 18089 Views: 5,712	IntraCV calculation [Power / Sample Size] Post reply
	Dear All, I have a question. <Pre-study, 1*2, Crossover design.> When calculating Intra CV, is there a case of 0? What should I do in such case? Edit: Category changed; see also this post #1. [Helmut]

BE-proff ● 2017-12-27 07:49 (2304 d 17:27 ago) @ youivab Posting: # 18090 Views: 4,917	IntraCV calculation Post reply
	Hi youivab, Unclear question. Are you talking about already done study?

youivab ☆ Korea, 2017-12-28 02:35 (2303 d 22:41 ago) @ BE-proff Posting: # 18105 Views: 4,839	IntraCV calculation Post reply
	❝ Unclear question. ❝ Are you talking about already done study? yes, already done and calculated AUClast, Cmax ...

kms.srinivas ☆ India, 2017-12-27 07:53 (2304 d 17:23 ago) @ youivab Posting: # 18092 Views: 4,897	IntraCV calculation Post reply
	❝ When calculating Intra CV, is there a case of 0? ❝ What should I do in such case? intra CV zero!!! Are you dealing with man or machine?!! which have also a little precision...

youivab
☆

Korea,
2017-12-28 02:37
(2303 d 22:39 ago)

@ kms.srinivas
Posting: # 18106
Views: 4,710

IntraCV calculation

Post reply

❝ intra CV zero!!!

❝ Are you dealing with man or machine?!! :confused: which have also a little precision...

I used SAS program.

This is the code I used.

ODS OUTPUT COVPARMS=RESIDUAL8;

PROC MIXED DATA=FED_VDCL;

  CLASS SUB P;

  MODEL LVD= P;

  RANDOM SUB;

  REPEATED/GRP=SUB SUB=SUB;

  LSMEANS /PDIFF CL ALPHA=0.1;

RUN; 

DATA RESIDUAL8;

  SET RESIDUAL8;

  IF COVPARM NE 'Residual' THEN DELETE;

  INTRACV=SQRT(EXP(ESTIMATE)-1)*100;

RUN;

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer. Tabulators changed to spaces and BBcoded; see also this post #5 and #6. [Helmut]

GM
★

India,
2017-12-28 07:56
(2303 d 17:19 ago)

@ youivab
Posting: # 18109
Views: 4,616

IntraCV calculation

Post reply

❝ This is the code I used.

❝

❝ ODS OUTPUT COVPARMS=RESIDUAL8;

❝ PROC MIXED DATA=FED_VDCL;


❝   CLASS SUB P;

❝   MODEL LVD= P;

❝   RANDOM SUB;

❝   REPEATED/GRP=SUB SUB=SUB;

❝   LSMEANS /PDIFF CL ALPHA=0.1;
❝ RUN; 
❝ DATA RESIDUAL8;

❝   SET RESIDUAL8;

❝   IF COVPARM NE 'Residual' THEN DELETE;

❝   INTRACV=SQRT(EXP(ESTIMATE)-1)*100;

❝ RUN;

Hi Youivab,

My understanding as per this code, this is Parallel Design.

I think, because of random effect in the model, the inter CV is zero.

Regards,
GM

—
Best Regards,
GM

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