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youivab
Junior

Korea,
2017-12-27 06:20
(edited by youivab on 2017-12-28 01:38)

Posting: # 18089
Views: 2,012
 

 IntraCV calculation [Power / Sample Size]

Dear All,

I have a question.

<Pre-study, 1*2, Crossover design.>

When calculating Intra CV, is there a case of 0?
What should I do in such case?


Edit: Category changed; see also this post #1. [Helmut]
BE-proff
Senior

Russia,
2017-12-27 06:49

@ youivab
Posting: # 18090
Views: 1,743
 

 IntraCV calculation

Hi youivab,

Unclear question.
Are you talking about already done study?
youivab
Junior

Korea,
2017-12-28 01:35

@ BE-proff
Posting: # 18105
Views: 1,607
 

 IntraCV calculation

» Unclear question.
» Are you talking about already done study?

yes, already done and calculated AUClast, Cmax ...
kms.srinivas
Junior

India,
2017-12-27 06:53
(edited by kms.srinivas on 2017-12-27 07:18)

@ youivab
Posting: # 18092
Views: 1,708
 

 IntraCV calculation

» When calculating Intra CV, is there a case of 0?
» What should I do in such case?

intra CV zero!!!
Are you dealing with man or machine?!! :confused: which have also a little precision...
youivab
Junior

Korea,
2017-12-28 01:37

@ kms.srinivas
Posting: # 18106
Views: 1,621
 

 IntraCV calculation

» intra CV zero!!!
» Are you dealing with man or machine?!! :confused: which have also a little precision...

I used SAS program.

This is the code I used.

ODS OUTPUT COVPARMS=RESIDUAL8;
PROC MIXED DATA=FED_VDCL;
  CLASS SUB P;
  MODEL LVD= P;
  RANDOM SUB;
  REPEATED/GRP=SUB SUB=SUB;
  LSMEANS /PDIFF CL ALPHA=0.1;
RUN;
DATA RESIDUAL8;
  SET RESIDUAL8;
  IF COVPARM NE 'Residual' THEN DELETE;
  INTRACV=SQRT(EXP(ESTIMATE)-1)*100;
RUN;



Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer. Tabulators changed to spaces and BBcoded; see also this post #5 and #6. [Helmut]
GM
Junior

India,
2017-12-28 06:56

@ youivab
Posting: # 18109
Views: 1,575
 

 IntraCV calculation

» This is the code I used.
»
» ODS OUTPUT COVPARMS=RESIDUAL8;
» PROC MIXED DATA=FED_VDCL;
»   CLASS SUB P;
»   MODEL LVD= P;
»   RANDOM SUB;
»   REPEATED/GRP=SUB SUB=SUB;
»   LSMEANS /PDIFF CL ALPHA=0.1;
» RUN;
» DATA RESIDUAL8;
»   SET RESIDUAL8;
»   IF COVPARM NE 'Residual' THEN DELETE;
»   INTRACV=SQRT(EXP(ESTIMATE)-1)*100;
» RUN;


Hi Youivab,

My understanding as per this code, this is Parallel Design.

I think, because of random effect in the model, the inter CV is zero.

Regards,
GM

Best Regards,
GM
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