# Bioequivalence and Bioavailability Forum 00:14 CET

Mohamed Yehia
Junior

Egypt,
2017-10-29 17:00

Posting: # 17941
Views: 1,748

## CI equation for 4 Period, 2 sequences "Full Replicate" [RSABE / ABEL]

Dear All,

I want to know the equation used to calculate the CI for 4 period, 2 sequences BE study using sequences:

Seq1: TRTR
Seq2: RTRT

According to my knowledge the Degree of Freedom used in the equation is (n1+n2)-2. However, I am afraid that the DF shall be 3n-4. So, which one shall I use

Thanks.
Helmut
Hero

Vienna, Austria,
2017-10-29 19:02

@ Mohamed Yehia
Posting: # 17942
Views: 1,451

## DF for 4 Period, 2 sequences "Full Replicate"

Salam Mohamed,

» […] 4 period, 2 sequences BE study using sequences:
» […] the DF shall be 3n-4.

Correct. If you have unequal sequences 3(n1+n2)–4.

Cheers,
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼
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Mohamed Yehia
Junior

Egypt,
2017-10-29 19:50

@ Helmut
Posting: # 17943
Views: 1,445

## DF for 4 Period, 2 sequences "Full Replicate"

» Salam Mohamed,

Thanks
»
» » […] 4 period, 2 sequences BE study using sequences:
» » […] the DF shall be 3n-4.
»
» Correct. If you have unequal sequences 3(n1+n2)-4

Thanks Helmut for the clarification
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