Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-06-18 23:16 UTC (UTC+2h)
ElMaestro
Hero

Denmark,
2017-10-27 12:58

Posting: # 17933
Views: 1,412
 

 Earth-mover's distance [Nonparametrics]

Hi all,

re. FDA Ciclosporine draft guidance:

Does anyone know where I should start to get to grips with Earth-mover's distance for real and in practice?
Wikipedia, the reference indicated in the guidance and some random googling hasn't given me a solid basis for understanding anything, much less for doing anything of value with it.

Note that the footnote opens up the possibility of using some other statistical similarity measures, and I hope to go that way, but let us for the purpose of this thread discuss EMD only :-D:confused::pirate:

if (3) 4

Best regards,
ElMaestro

"(...) targeted cancer therapies will benefit fewer than 2 percent of the cancer patients they’re aimed at. That reality is often lost on consumers, who are being fed a steady diet of winning anecdotes about miracle cures." New York Times (ed.), June 9, 2018.
Helmut
Hero
avatar
Homepage
Vienna, Austria,
2017-10-27 13:17

@ ElMaestro
Posting: # 17934
Views: 1,233
 

 Earth-mover's distance

Hi ElMaestro,

» […] Earth-mover's distance …

OT: Wow, what a term! Reminds me on

Δῶς μοι πᾶ στῶ καὶ τὰν γᾶν κινάσω.
Give me the place to stand, and I shall move the earth.
    Archimedes of Syracuse


Bonus question: Who the heck is Stolfi?

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
ElMaestro
Hero

Denmark,
2017-10-27 13:24

@ Helmut
Posting: # 17935
Views: 1,209
 

 Earth-mover's distance

Hi Hötzi,

» Bonus question: Who the heck is Stolfi?

What????
I don't think I know anyone with that name or with that handle. Sounds like a German side dish.
"Einmal Currywurst mit Stolfi und dazu ein Fassbier, bitte!"

if (3) 4

Best regards,
ElMaestro

"(...) targeted cancer therapies will benefit fewer than 2 percent of the cancer patients they’re aimed at. That reality is often lost on consumers, who are being fed a steady diet of winning anecdotes about miracle cures." New York Times (ed.), June 9, 2018.
Helmut
Hero
avatar
Homepage
Vienna, Austria,
2017-10-27 13:32

@ ElMaestro
Posting: # 17936
Views: 1,207
 

 Earth-mover's distance

Hi ElMaestro,

» » Bonus question: Who the heck is Stolfi?
» I don't think I know anyone with that name or with that handle.

Acc. to the original publication the lad* who coined the term (personal communication 1994).

» Sounds like a German side dish.
» "Einmal Currywurst mit Stolfi und dazu ein Fassbier, bitte!"

Reminds me on the German release of Disney’s Lady and the Tramp (“Susi und Strolch”).


Edit: Jorge Stolfi.

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
nobody
Senior

2017-10-28 15:31

@ Helmut
Posting: # 17937
Views: 1,112
 

 Earth-mover's distance

"Informally, if the distributions are interpreted as two different ways of piling up a certain amount of dirt over the region D, the EMD is the minimum cost of turning one pile into the other; where the cost is assumed to be amount of dirt moved times the distance by which it is moved."

https://en.wikipedia.org/wiki/Earth_mover%27s_distance

Seriously?

Mayby some quantum effects might come into play... I'm out (never in).

Kindest regards, nobody
Back to the forum Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
18,384 posts in 3,905 threads, 1,172 registered users;
online 13 (1 registered, 12 guests [including 11 identified bots]).

You can’t fix by analysis
what you bungled by design.    Richard J. Light, Judith D. Singer, John B. Willett

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed