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Amira ☆ Egypt, 2017-09-26 14:26 (2402 d 21:54 ago) Posting: # 17829 Views: 6,245 |
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Hello, Atorvastatin Calcium is known as highly variable drug but when we conducted a BE study on it, the results gave low intra-subject Variability (18%) and that's inconsistent with the usual results. What could be the reason/s for this? Thank you. Edit: Category changed; see also this post #1. [Helmut] |
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ElMaestro ★★★ Denmark, 2017-09-26 14:51 (2402 d 21:29 ago) @ Amira Posting: # 17830 Views: 4,972 |
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Hi Amira, Chance? Better assay? Design differences? Lesser within-batch variability (-ies) than in the studies you compare to? — Pass or fail! ElMaestro |
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nobody nothing 2017-09-27 12:11 (2402 d 00:09 ago) @ ElMaestro Posting: # 17832 Views: 4,971 |
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❝ Chance? ❝ Better assay? ❝ Design differences? ❝ Lesser within-batch variability (-ies) than in the studies you compare to? https://www.ncbi.nlm.nih.gov/pubmed/22167570 https://www.ncbi.nlm.nih.gov/pubmed/21548957 https://www.ncbi.nlm.nih.gov/pubmed/20818835 — Kindest regards, nobody |
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Helmut ★★★   Vienna, Austria, 2017-09-27 13:05 (2401 d 23:15 ago) @ nobody Posting: # 17833 Views: 4,954 |
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Hi ElMaestro & nobody, ❝ ❝ Chance? ❝ Maybe, but... Quick calculations based on published CV (~35%), full replicate designs (n 40–64): Very, very unlikely; p <10–16. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz