nobody nothing 2017-08-07 19:14 (2452 d 06:44 ago) Posting: # 17673 Views: 9,695 |
|
Hi again! Found this here: https://www.ncbi.nlm.nih.gov/pubmed/28257283 Maybe I need some holiday, after all, but if I understand this correctly, the authors say, CVintra for Cmax is generally higher than for AUC, therefore use AUC to estimate the sample size of your study. Did I get this right? Any thoughts on this approach? — Kindest regards, nobody |
Helmut ★★★ Vienna, Austria, 2017-08-07 20:40 (2452 d 05:18 ago) @ nobody Posting: # 17674 Views: 8,819 |
|
Hi nobody, ❝ Found this here: ❝ https://www.ncbi.nlm.nih.gov/pubmed/28257283 ❝ […] if I understand this correctly, the authors say, CVintra for Cmax is generally higher than for AUC, therefore use AUC to estimate the sample size of your study. Ah – the formerly pink, now black journal. ❝ Did I get this right? At least this is what the last sentence of the abstract says: “Hence, CV derived from AUC instead of Cmax should be used in sample-size calculation to achieve a sufficient, yet practical, test power. ” ❝ Any thoughts on this approach? Outright bizarre. Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2017-08-07 21:52 (2452 d 04:06 ago) @ Helmut Posting: # 17675 Views: 8,716 |
|
❝ ❝ Any thoughts on this approach? ❝ ❝ Outright bizarre. Good, so I'm not alone... ❝ Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share? Would not spend a single cent on such a nonsense. How does somethink like that survive peer review? Now that is published it will be referenced and used as "scientific basis" for further conclusions/studies. Nightmare. How to get such trash retracted? ***deeply depressed*** — Kindest regards, nobody |
Helmut ★★★ Vienna, Austria, 2017-08-07 22:29 (2452 d 03:28 ago) @ nobody Posting: # 17676 Views: 8,775 |
|
Hi nobody, ❝ Would not spend a single cent on such a nonsense. How does somethink like that survive peer review? ❝ Now that is published it will be referenced and used as "scientific basis" for further conclusions/studies. That’s a slow-burn! My memory-span is better than ElMaestro’s (two weeks?) but it took me a while to recall. I was asked in May 2016 about my opinion. The editor wasn’t even sure whether he should reject the manuscript right away or initiate the review process. My response was: The manuscript is without any scientific value. I used some strong words which I won’t post here. Will send it to you by PM.Obviously the editor didn’t listen to me and the reviewers were blind. Explains why it is called “blind review”. ❝ How to get such trash retracted? Practically impossible. You could writer a letter to the editor. Detlew and I tried that once, but the procedure was endless and after months (!) the editor of Pharm Res. suggested we should submit a full MS instead. This was not our intention. We didn’t discover anything new. Only wanted to point out that another article (which made it through the review) was pooh. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2017-08-07 23:31 (2452 d 02:27 ago) @ Helmut Posting: # 17677 Views: 8,768 |
|
...maybe you should add a special category "Trash science" to the forum to collect such "gems" and make the scientific assessment public via Google... — Kindest regards, nobody |
ElMaestro ★★★ Denmark, 2017-08-08 01:04 (2452 d 00:54 ago) @ nobody Posting: # 17679 Views: 8,771 |
|
Hi nobody, ❝ Any thoughts on this approach? What a load of absolute nonsense. And it is of a dangerous kind because it:
I am serious, this is deeply problematic cf. e.g. the Helsinki Declaration and the general GCP principles. This is much worse than the recent Midichloria case. Check the reference list in that publication for a good laugh, by the way. Edit: Background “Predatory Journals Hit By ‘Star Wars’ Sting” [Helmut] — Pass or fail! ElMaestro |
nobody nothing 2017-08-08 12:06 (2451 d 13:52 ago) @ ElMaestro Posting: # 17682 Views: 8,582 |
|
...recently saw a nice documentation on the Renaissance. How the "big disrupters" cleaned up the old knowledge and created a completely new "awareness". Same today with all these google-amazon-uber-tesla guys, and then the rest of the world thinks they can do the same with the knowledge in their "field of expertise"... — Kindest regards, nobody |
jag009 ★★★ NJ, 2017-08-09 08:21 (2450 d 17:37 ago) @ nobody Posting: # 17685 Views: 8,569 |
|
❝ Any thoughts on this approach? Stay away... John |
nobody nothing 2017-08-09 19:11 (2450 d 06:47 ago) @ jag009 Posting: # 17686 Views: 8,573 |
|
https://www.theatlantic.com/science/archive/2016/09/the-inevitable-evolution-of-bad-science/500609/ ... — Kindest regards, nobody |