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Back to the forum  2018-06-22 00:15 UTC (UTC+2h)
Mohamed Yehia
Junior

Egypt,
2017-07-29 20:10

Posting: # 17626
Views: 1,847
 

 Confidence Interval For Tmax [Nonparametrics]

Dear All,

I want to know whether we can use transformed data on Tmax to check for CI?. AS it was stated previously that if we will take Tmax into statistical considerations we will take untransformed tmax not transformed ones.


Edit: Category changed; see also this post #1. [Helmut]
ElMaestro
Hero

Denmark,
2017-07-29 21:30

@ Mohamed Yehia
Posting: # 17628
Views: 1,597
 

 Confidence Interval For Tmax

Hi M.Y.,

» I want to know whether we can use transformed data on Tmax to check for CI?. AS it was stated previously that if we will take Tmax into statistical considerations we will take untransformed tmax not transformed ones.

CI's on Tmax are not much in use anymore. Don't bother.
I mainly see them popping up nowadays when applicants find themselves in desperate situations with deficiency letters and imminent rejection fears. That's when they try to generate all sorts of supportive funky BE results (which were never stipulated in any protocol or SAP) in the hope that quantity of tests outweighs the quality of a few well-chosen tests. :-):-):-)

if (3) 4

Best regards,
ElMaestro

"(...) targeted cancer therapies will benefit fewer than 2 percent of the cancer patients they’re aimed at. That reality is often lost on consumers, who are being fed a steady diet of winning anecdotes about miracle cures." New York Times (ed.), June 9, 2018.
Mohamed Yehia
Junior

Egypt,
2017-07-29 21:38

@ ElMaestro
Posting: # 17629
Views: 1,611
 

 Confidence Interval For Tmax

» CI's on Tmax are not much in use anymore. Don't bother.

Hi Elmaestro,

Yes, I know that. However, I found a SAS report that generate a Non parametric analysis test on Ln transformed Tmax; thats why I am wondering is that accepted or not.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Helmut
Hero
avatar
Homepage
Vienna, Austria,
2017-07-30 12:41

@ Mohamed Yehia
Posting: # 17630
Views: 1,596
 

 Confidence Interval For Tmax

Hi Mohamed,

first of all, please read this post and follow the forum’s policy (you confirmed with the registration that you have read and accepted it)! I had to edit all of your posts… :-(

» […] However, I found a SAS report that generate a Non parametric analysis test on Ln transformed Tmax;

tmax comes from an ordinal scale and therefore, follows a discrete distribution (dependent on the sampling schedule). Hence, a nonparametric analysis is correct in principle. However, transformations are only allowed for data coming from a ratio scale (continuous with a true zero point).
Therefore, the report you found is crap. SAS is a fine piece of software but only as good as the user. This one probably was not qualified for his/her job.

Common language will give you a hint whether an additive model (raw data) or a multiplicative model (log-transformed data) should be used. Every time you say “X is Y% of Z” or “X is Y% lower than Z” you should apply a log-transformation (e.g., Cmax). If you say “the difference of X to Z is Y” you should use the raw data (e.g., tmax).

Cheers,
Helmut Schütz
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