Mohamed Yehia
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Egypt,
2017-07-28 23:00
(2456 d 07:28 ago)

Posting: # 17621
Views: 4,525
 

 T1 and T2 of Schuirmann test for bioequivalence [General Sta­tis­tics]

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Dear All;

I want to know how to calculate the T1 and T2 of schuirmann test for 2*2 crossover bioequivalence study.... I found this equation, i want to know whether it is correct or wrong?.

Thanks in advance.

[image]

Edit: Category changed; see also this post #1. [Helmut]
 
Helmut
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Vienna, Austria,
2017-07-29 03:09
(2456 d 03:19 ago)

@ Mohamed Yehia
Posting: # 17622
Views: 3,879
 

 T1 and T2 of TOST

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Salam Mohamed,

❝ I want to know how to calculate the T1 and T2 of schuirmann test for 2*2 crossover bioequivalence study.... I found this equation, i want to know whether it is correct or wrong?.


Correct for a parallel design, wrong for a 2×2×2 crossover. Use these ones:

[image]

where YT and YR are the geometric least squares (aka marginal, adjusted) means of T and R, θ1 and θ2 the lower und upper limits of the acceptance range, σw the √MSE from ANOVA, and n1, n2 the number of subjects / sequence.


BTW, consider reading the original paper* instead of trusting in what you find on the internet (including this site, of course).

  • Schuirmann DJ. A comparison of the Two One-Sided Tests Procedure and the Power Approach for Assessing the Equivalence of Average Bioavailability. J Pharmacokin Biopharm. 1987;15(6):657–80. doi:10.1007/BF01068419.
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Mohamed Yehia
★    

Egypt,
2017-07-29 22:38
(2455 d 07:50 ago)

@ Helmut
Posting: # 17623
Views: 3,590
 

 T1 and T2 of TOST

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Salam Helmut,

Thanks a lot for your assistance and kind advice. I will follow the equation you send.

Thanks again ;)

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
 
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