Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2017-08-24 06:56 CEST (UTC+2h)
 
Mohamed Yehia
Junior

Egypt,
2017-07-28 21:00

Posting: # 17621
Views: 429
 

 T1 and T2 of Schuirmann test for bioequivalence [General Sta­tis­tics]

Dear All;

I want to know how to calculate the T1 and T2 of schuirmann test for 2*2 crossover bioequivalence study.... I found this equation, i want to know whether it is correct or wrong?.

Thanks in advance.

[image]


Edit: Category changed; see also this post #1. [Helmut]
Helmut
Hero
Homepage
Vienna, Austria,
2017-07-29 01:09

@ Mohamed Yehia
Posting: # 17622
Views: 351
 

 T1 and T2 of TOST

Salam Mohamed,

» I want to know how to calculate the T1 and T2 of schuirmann test for 2*2 crossover bioequivalence study.... I found this equation, i want to know whether it is correct or wrong?.

Correct for a parallel design, wrong for a 2×2×2 crossover. Use these ones:

[image]

where YT and YR are the geometric least squares (aka marginal, adjusted) means of T and R, θ1 and θ2 the lower und upper limits of the acceptance range, σw the √MSE from ANOVA, and n1, n2 the number of subjects / sequence.


BTW, consider reading the original paper* instead of trusting in what you find on the internet (including this site, of course).


  • Schuirmann DJ. A comparison of the Two One-Sided Tests Procedure and the Power Approach for Assessing the Equivalence of Average Bioavailability. J Pharmacokin Biopharm. 1987;15(6):657–80. doi:10.1007/BF01068419 free resource

[image]All the best,
Helmut Schütz 
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes
Mohamed Yehia
Junior

Egypt,
2017-07-29 20:38

@ Helmut
Posting: # 17623
Views: 254
 

 T1 and T2 of TOST

Salam Helmut,

Thanks a lot for your assistance and kind advice. I will follow the equation you send.

Thanks again ;)


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
Back to the forum Activity
 Thread view
Bioequivalence and Bioavailability Forum | Admin contact
17,243 Posts in 3,687 Threads, 1,057 registered users;
25 users online (0 registered, 25 guests).

I try not to think with my gut.
If I’m serious about understanding the world,
thinking with anything besides my brain, as tempting as that might be,
is likely to get me into trouble.    Carl Sagan

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed