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Achievwin ★ US, 2017-07-23 18:04 (2459 d 02:53 ago) Posting: # 17597 Views: 5,365 |
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Can anyone share R-code for computing ABE and RSABE calculations along with plots for ANDA starting with plasma concentration and randomization code spreadsheets. Much appreciate your help AchievWin |
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Helmut ★★★   Vienna, Austria, 2017-07-23 19:17 (2459 d 01:40 ago) @ Achievwin Posting: # 17598 Views: 4,658 |
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Hi AchievWin, for ABE package bear can do the job. But: linear model (all effects fixed). However, as long as you don’t use incomplete data (periods missing) the outcomes (residual error, PE) of a fixed effects model (like SAS Proc GLM) and a mixed effects model (SAS Proc Mixed) are identical.RSABE according to the FDA’s method is not possible in R, since the “philosophies” (better: churches) of mixed effect models of SAS and R are different. Many tried, all failed. Stop searching. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Achievwin ★ US, 2017-07-24 22:20 (2457 d 22:37 ago) @ Helmut Posting: # 17604 Views: 4,561 |
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Thanks a bunch if we develop an R-code for RSABE (may be futile effort) we will share with the forum. Regards, |
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Helmut ★★★ Vienna, Austria, 2017-07-24 22:47 (2457 d 22:10 ago) @ Achievwin Posting: # 17605 Views: 4,630 |
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Hi AchievWin, ❝ […] if we develop an R-code for RSABE (may be futile effort) we will share with the forum. Yes, please! Difficult but not impossible.  IMHO, it would require a major rewrite of already available code. As a starter (!) have a look at the sources of package lmerTest, function lmer(). Good luck!— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz