Achievwin
★    

US,
2017-07-23 18:04
(2439 d 22:13 ago)

Posting: # 17597
Views: 5,280
 

 Does anyone have R-code for BE computations [🇷 for BE/BA]

Can anyone share R-code for computing ABE and RSABE calculations along with plots for ANDA starting with plasma concentration and randomization code spreadsheets.

Much appreciate your help

AchievWin
Helmut
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Vienna, Austria,
2017-07-23 19:17
(2439 d 21:00 ago)

@ Achievwin
Posting: # 17598
Views: 4,583
 

 package bear

Hi AchievWin,

for ABE package bear can do the job. But: linear model (all effects fixed). However, as long as you don’t use incomplete data (periods missing) the outcomes (residual error, PE) of a fixed effects model (like SAS Proc GLM) and a mixed effects model (SAS Proc Mixed) are identical.
RSABE according to the FDA’s method is not possible in R, since the “philosophies” (better: churches) of mixed effect models of SAS and R are different. Many tried, all failed. Stop searching.

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Achievwin
★    

US,
2017-07-24 22:20
(2438 d 17:57 ago)

@ Helmut
Posting: # 17604
Views: 4,487
 

 package bear

Thanks a bunch if we develop an R-code for RSABE (may be futile effort) we will share with the forum.

Regards,
Helmut
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Vienna, Austria,
2017-07-24 22:47
(2438 d 17:30 ago)

@ Achievwin
Posting: # 17605
Views: 4,557
 

 R-code for RSABE

Hi AchievWin,

❝ […] if we develop an R-code for RSABE (may be futile effort) we will share with the forum.


Yes, please! Difficult but not impossible. :-D IMHO, it would require a major rewrite of already available code. As a starter (!) have a look at the sources of package lmerTest, function lmer(). Good luck!

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