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Back to the forum  2018-06-22 02:15 CEST (UTC+2h)
Achievwin
Junior

US,
2017-07-23 16:04

Posting: # 17597
Views: 2,077
 

 Does anyone have R-code for BE computations [R for BE/BA]

Can anyone share R-code for computing ABE and RSABE calculations along with plots for ANDA starting with plasma concentration and randomization code spreadsheets.

Much appreciate your help

AchievWin
Helmut
Hero
avatar
Homepage
Vienna, Austria,
2017-07-23 17:17

@ Achievwin
Posting: # 17598
Views: 1,806
 

 package bear

Hi AchievWin,

for ABE package bear can do the job. But: linear model (all effects fixed). However, as long as you don’t use incomplete data (periods missing) the outcomes (residual error, PE) of a fixed effects model (like SAS Proc GLM) and a mixed effects model (SAS Proc Mixed) are identical.
RSABE according to the FDA’s method is not possible in R, since the “philosophies” (better: churches) of mixed effect models of SAS and R are different. Many tried, all failed. Stop searching.

Cheers,
Helmut Schütz
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Achievwin
Junior

US,
2017-07-24 20:20

@ Helmut
Posting: # 17604
Views: 1,719
 

 package bear

Thanks a bunch if we develop an R-code for RSABE (may be futile effort) we will share with the forum.

Regards,
Helmut
Hero
avatar
Homepage
Vienna, Austria,
2017-07-24 20:47

@ Achievwin
Posting: # 17605
Views: 1,728
 

 R-code for RSABE

Hi AchievWin,

» […] if we develop an R-code for RSABE (may be futile effort) we will share with the forum.

Yes, please! Difficult but not impossible. :-D IMHO, it would require a major rewrite of already available code. As a starter (!) have a look at the sources of package lmerTest, function lmer(). Good luck!

Cheers,
Helmut Schütz
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