Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2017-07-23 20:43 CEST (UTC+2h)
 
Ashwitha
Junior

India,
2017-07-09 15:02

Posting: # 17529
Views: 225
 

 BLLOQ (or NQ-Non Quantifiable Concentrations) in PK Concentration data [NCA / SHAM]

Hello,

I am new to the group. But I have read couple of discussions recently and found very informative, thanks for sharing the knowledge.

I am a Programmer in Clinical domain, I develop data sets and reports on various domains.

I have a query regarding BLLOQ or NQ values in PK concentration data.
We follow certain rules to impute the NQ's in the data,
1. if there is single NQ between measurable concentrations we impute it to Null,
2. if it is leading NQ's we impute it to Zero and
3. if it is More than one consecutive NQ between measurable concentrations we impute the NQ value to Null.

So, I have done some research, not thorough, on understanding this and I found that these imputations are carefully done for input data needs for WinNonlin software and also to neither overestimate or underestimate AUC.

Could anyone please help me understand why these imputations are done, as i am confused.

Please also suggest Literature to understand the topics.

Thank you,
Ashwitha


Edit: Category changed; see also this post #1. [Helmut]
Back to the forum Activity
 Thread view
Bioequivalence and Bioavailability Forum | Admin contact
17,098 Posts in 3,667 Threads, 1,051 registered users;
15 users online (0 registered, 15 guests).

They must find it difficult… those who have taken authority as the truth,
rather than truth as the authority.    Gerald Massey

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed