VSP ☆ India, 2017-04-25 20:28 (2551 d 01:30 ago) Posting: # 17265 Views: 4,156 |
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Hello, Please guide me on following question. Can we define the absorption phase and elimination phase with concentration time data/Plot? Thanks in advance. VSP Edit: Category changed; see also this post #1. [Helmut] |
Helmut ★★★ Vienna, Austria, 2017-04-26 15:26 (2550 d 06:31 ago) @ VSP Posting: # 17266 Views: 3,352 |
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Hi VSP, ❝ Can we define the absorption phase and elimination phase with concentration time data/Plot? There is no “absorption/elimination phase”. Both absorption / elimination start almost immediately with dosing. See here (ka > kel) and there (ka = kel; flip-flop PK). As long as drug is released from the formulation and dissolved, absorption continues until
i is the multiplier of tmax. Once you have an estimate of elimination you can obtain absorption f.i. by the method of residuals or by Wagner-Nelson’s.— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |