Maryam Junior Iran, 20170113 16:28 Posting: # 16946 Views: 2,412 

HI I want to run this procedure in sas9.1: proc ttest data=auc dist=lognormal tost(0.8, 1.25); but it had an error: How should I solve this problem? thanks 
Mahmoud Junior Jordan, 20170115 08:56 @ Maryam Posting: # 16947 Views: 2,141 

Dear Sir ===== For BE studies do not use the ttest paired data.if you need any results in BE study please send me your data in the following email mahmohsen111[at]yahoo.com Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! I activated the email link in your profile. [Helmut] 
Helmut Hero Vienna, Austria, 20170115 12:16 @ Mahmoud Posting: # 16948 Views: 2,133 

Salam Mahmoud, » Dear Sir I assume that Maryam is not a Sir. » For BE studies do not use the ttest paired data. We don’t know the design of Maryam’s study. What if it was not a crossover? Examples where a paired ttest would be correct indeed:
— All the best, Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes 
Maryam Junior Iran, 20170115 16:44 @ Helmut Posting: # 16951 Views: 2,101 

» We don’t know the design of Maryam’s study. » @Maryam: What is the structure of you data? I don’t speak SAS but which error did you get? Hi sir Maryam is not a sir thanks for your answer, my structure is a crossover study! actually I want to calculate 90% CI for BE parameters of test/reference! and I want to evaluate the effect of period, sequence, subject and treatment! I know how calculate these by formulations but I need a software to calculate these! would you please to guide me in this problem? thanks Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] 
DavidManteigas Regular Portugal, 20170117 15:35 @ Maryam Posting: # 16967 Views: 1,949 

@Maryam For a 2x2 crossover, the following code will get you everything you need (ods outputs LSMeandiffCL, LSMeans, AltErrTests and OverallANOVA) proc glm data=replicate; Formulation and Period p values come from OverallAnova, while sequence p value from AltErrTests. This code in principle will fit both EMA and FDA requirements for a 2x2 design. Although FDA requests subject within sequence as random effect, this will not change the result. 
Helmut Hero Vienna, Austria, 20170118 12:57 @ DavidManteigas Posting: # 16972 Views: 1,779 

Hi David, » proc glm data=replicate; <nitpicking> Why are you calling a data set of a 2×2 crossover » lsmeans formulation / adjust=t pdiff=control("R") CL alpha=0.10; I would remove adjust=t . There is nothing to adjust in a 2×2 crossover. See this thread.— All the best, Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes 
DavidManteigas Regular Portugal, 20170127 15:03 @ Helmut Posting: # 16996 Views: 1,137 

Hi Helmut, The reason for "Replicate" as the dataset name is because I took the code from the EMA Q&A Guideline and adapted it  but forgot to remove the misleading name I agree with you regarding the adjusment question. Nevertheless, as far as I understand the parameter does nothing if you leave it on the code. 
Maryam Junior Iran, 20170115 16:31 @ Mahmoud Posting: # 16950 Views: 2,107 

» For BE studies do not use the ttest paired data. Hi sir thanks for your answer. your are right! ttest paired does not use for BE studies. By SAS and ttest I want to calculate 90% CI for pharmacokinetics parameters of test/reference. would you please to help me to calculate 90% CI for pharmacokinetics parameters of test/reference by any softwares? can I use this calculation by SPSS? thanks Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] 
Mahmoud Junior Jordan, 20170115 14:36 @ Maryam Posting: # 16949 Views: 2,115 

» I want to run this procedure in sas9.1: » » proc ttest data=auc dist=lognormal tost(0.8, 1.25); » paired TestAUC*RefAUC; » run; Dear all ===== For the codes above you need to use SAS 9.3 Mahmoud Ph.D Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] 
Maryam Junior Iran, 20170115 16:50 @ Mahmoud Posting: # 16952 Views: 2,102 

» For the codes above you need to use SAS 9.3 Hi sir thanks for your answer, Do you know how I can correct these codes for SAS 9.1? because I have only SAS 9.1! thanks Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] 
Mahmoud Junior Jordan, 20170116 10:08 @ Maryam Posting: # 16954 Views: 2,063 

Dear Dr Please let me know what is the design for your data Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! Since you repeatedly did not follow the Policy, this is the first warning. [Helmut] 