Yura ★ Belarus, 2016-11-09 10:10 (2718 d 10:37 ago) Posting: # 16790 Views: 6,480 |
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Dear all Can I use design RTR | TRR for highly variable drugs? Thanks and regards |
d_labes ★★★ Berlin, Germany, 2016-11-09 13:01 (2718 d 07:47 ago) @ Yura Posting: # 16791 Views: 5,705 |
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Dear Yura ❝ Can I use design RTR | TRR for highly variable drugs? see this post and linked post within it. Search also the forum for "extra-reference design". Like Helmut I would not recommend this design, although it allows the estimation of the variability of the Reference and should therefore suitable for the evaluation via scaled ABE. Since the Test is never administered in period 3 I would expect difficulties if there is a period effect. Moreover the partial replicate design with sequences TRR|RTR|RRT is meanwhile the de facto standard if one goes with a three period design in evaluating scaled ABE for HVD/HVDP. — Regards, Detlew |
Yura ★ Belarus, 2016-11-10 13:18 (2717 d 07:29 ago) @ d_labes Posting: # 16794 Views: 5,542 |
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thank you very much Dear d_labes There was information in presentation about higt importance of sequence effect and toughening of level of its significance up to 0,1 (instead of 0,05) i. e. the effect of the period can be ignored Kind regards |
Helmut ★★★ Vienna, Austria, 2016-11-10 14:28 (2717 d 06:19 ago) @ Yura Posting: # 16795 Views: 5,609 |
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Hi Yura, ❝ There was information in presentation … May I ask: Which presentation? ❝ … about higt importance of sequence effect and toughening of level of its significance up to 0,1 (instead of 0,05) i. e. the effect of the period can be ignored α 0.1 was suggested in the past because of the low power of the test (between subjects). But:
— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Yura ★ Belarus, 2016-11-10 14:49 (2717 d 05:58 ago) @ Helmut Posting: # 16796 Views: 5,548 |
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thank you very much Dear Helmut |
mittyri ★★ Russia, 2016-11-09 13:13 (2718 d 07:34 ago) @ Yura Posting: # 16792 Views: 5,559 |
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Dear Yura, Radio Yerevan’s answer: “In principle yes, but you have to demonstrate very strong reasons not to use recommended one.” — Kind regards, Mittyri |