hirenpharm
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Ahmedabad,
2016-04-15 21:41
(2904 d 04:53 ago)

Posting: # 16207
Views: 4,709
 

 comparative bio­avail­ability [General Sta­tis­tics]

Hi Helmut,

Can you please suggest when to use TOST (two one sided t-tests) for comparative bio availability in stead of a standard ANOVA approach using period, treatment, subjects as random effects? I was reading through
https://sphhp.buffalo.edu/content/dam/sphhp/biostatistics/Documents/techreports/UB-Biostatistics-TR1107.pdf
And also-
two one-sided tests” (TOST) proposed by Schuirmann (1987)

http://www.ncss.com/wp-content/themes/ncss/pdf/Procedures/PASS/Equivalence_Tests_for_Two_Means_using_Differences.pdf

Dr. Hiren Mehta
Helmut
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Vienna, Austria,
2016-04-18 16:02
(2901 d 10:33 ago)

@ hirenpharm
Posting: # 16213
Views: 3,620
 

 100(1–2α) CI

Hi Hiren,

❝ Hi Helmut,


     Not interested in the opinions of other members?


All guidelines I’m aware of recommend a 100(1–2α) confidence interval – not TOST. See also this post and the linked references.

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hirenpharm
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Ahmedabad,
2016-04-21 18:28
(2898 d 08:06 ago)

@ Helmut
Posting: # 16231
Views: 3,471
 

 100(1–2α) CI

thanks Helmut. Obviously all members' opinion matters!
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