BEproff Senior Russia, 20160406 21:39 Posting: # 16167 Views: 4,632 

Hi All, Is it possible to calculate number of subjects for steady state study with PowerTOST? What parameters are required? Edit: Category changed. [Helmut] 
d_labes Hero Berlin, Germany, 20160407 10:54 @ BEproff Posting: # 16168 Views: 4,110 

Dear BEproff, » Is it possible to calculate number of subjects for steady state study with PowerTOST? Of course, it's the Gold Standard ! » What parameters are required? The same as for sample size estimation for other types of BE studies.
— Regards, Detlew 
BEproff Senior Russia, 20160407 15:42 @ d_labes Posting: # 16171 Views: 4,022 

Hi d_labes, Could you share a sample of script for calculation? How to write design type in it? 
Helmut Hero Vienna, Austria, 20160407 16:09 @ BEproff Posting: # 16172 Views: 4,012 

H BEproff, » Could you share a sample of script for calculation? As Detlew wrote above » » More arguments of the sample size estimation functions in PowerTOST you may find in the man pages. Type help(package=PowerTOST) in the Rconsole or use the onlineversion. Most interesting functions are sampleN.TOST() for ABE, sampleN.scABEL() for the EMA’s ABEL, and sampleN.RSABE() for the FDA’s RSABE.At the end of all man pages you will find examples. » How to write design type in it? RTFM (argument design ) of the sampleN functions:
known.designs() . The column design shows the argument to specify in the functions (e.g., design="2x2x2" or design="parallel" ).— Regards, Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes 
BEproff Senior Russia, 20160409 20:15 @ Helmut Posting: # 16176 Views: 3,823 

Hi Helmut, I have tried to enter known.designs() and it returned the following list: 1 2 parallel groups Where is my so wanted steady state design? 
Helmut Hero Vienna, Austria, 20160410 00:50 @ BEproff Posting: # 16177 Views: 3,771 

BEproff, » Where is my so wanted steady state design? Are you a troll? You estimate the sample sample for the PK metrics of interest (see this post) and the values Detlew stated already above. Only you know which design you will use! Plug the argument in one of PowerTOST ’s functions. What’s your problem‽— Regards, Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes 
BEproff Senior Russia, 20160410 13:42 @ Helmut Posting: # 16178 Views: 3,740 

Hi Helmut, I am not a troll :) Below is a TOST example for calculation of parallel design study. sampleN.TOST(CV=0.23, design="parallel") What word must be written instead of "parallel" for calculate sample for steady state study? 
Helmut Hero Vienna, Austria, 20160410 13:48 @ BEproff Posting: # 16179 Views: 3,737 

Hi BEproff, how shall I know in which design you plan to perform the steady state study? » What word must be written instead of "parallel" for calculate sample for steady state study? Heck, a steady state study can be done in any of the designs given by known.designs() !If it’s not a parallel but a simple crossover use design="2x2x2" . If it’s a fourperiod full replicate use design="2x2x4" , et cetera, ad libitum, ad nauseam.— Regards, Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. ☼ Science Quotes 
BEproff Senior Russia, 20160412 13:36 @ Helmut Posting: # 16186 Views: 3,528 

Hi Helmut, Yes! Now it is clear to me! Many thanks for your help and patience. 