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jag009 ★★★ NJ, 2015-07-15 18:39 (3198 d 04:49 ago) Posting: # 15088 Views: 7,353 |
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Hi all, Does anyone have experience with raloxifene? If so, what is the intrasubject cv? According to literature it's a HVD (ISCV>=30) but no exact figure. Thanks John Edit: Category changed. [Helmut] |
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Mauricio Sampaio ★ Brazil, 2015-07-17 02:59 (3196 d 20:29 ago) @ jag009 Posting: # 15098 Views: 6,059 |
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Between 30 - 45%. |
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d_labes ★★★ Berlin, Germany, 2015-07-17 10:05 (3196 d 13:23 ago) @ Mauricio Sampaio Posting: # 15099 Views: 6,018 |
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Hi John, hi Mauricio, ❝ Between 30 - 45%. Confirmed if CV for Cmax is meant: 1 study pivotal 36 subj. in 2005: CV(Cmax) ~29%; CV(AUC) ~22% 1 study pilot, 12 subj. in 2010: CV(Cmax) ~41%; CV(AUC) ~ 15% — Regards, Detlew |
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drgunasakaran1 ★★  2015-07-19 18:46 (3194 d 04:42 ago) @ jag009 Posting: # 15105 Views: 5,963 |
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Dear Mr John, ❝ Does anyone have experience with raloxifene? If so, what is the intrasubject cv? According to literature it's a HVD (ISCV>=30) but no exact figure. The literature reported Intrasubject variability of Raloxifene for Cmax was 39.59% as per the bioequivalence study submitted to EMA. Reference: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001075/WC500091423.pdf — Dr S Gunasakaran MBBS MD Disclaimer: The replies/posts are my personal opinions and it does not represent my company views on the same. |
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jag009 ★★★ NJ, 2015-07-20 08:42 (3193 d 14:46 ago) @ drgunasakaran1 Posting: # 15106 Views: 5,838 |
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Thanks everyone. PS Thanks v much for link drgunasakaran1. That is very helpful! John |
Ing. Helmut Schütz