john john ☆ Spain, 2015-05-06 14:16 (3249 d 20:18 ago) Posting: # 14756 Views: 13,594 |
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Hullo I'm looking for the inter-subject variability of the Cmax of oral hydroxychloroquine. Thanks Edit: Category changed. [Helmut] |
Helmut ★★★ Vienna, Austria, 2015-05-06 15:18 (3249 d 19:16 ago) @ john john Posting: # 14760 Views: 13,249 |
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Hi John(s), ❝ I'm looking for the inter-subject variability of the Cmax of oral hydroxychloroquine. I guess you mean CVtotal? CVinter is only accessible in a crossover study. BE studies of hydroxychloroquine are performed in a parallel design due to its long half-life. In the future please first. If the CV was not given, I calculated it from the CIs and sample sizes:
Liu’s CVs are simply bizarre. Unbelievable that such a paper passed the peer-review.
— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
john john ☆ Spain, 2015-05-06 15:28 (3249 d 19:06 ago) @ Helmut Posting: # 14761 Views: 12,035 |
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Helmut ★★★ Vienna, Austria, 2015-05-06 17:40 (3249 d 16:54 ago) @ john john Posting: # 14764 Views: 12,032 |
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Hi John × 2 ❝ I want the CV inter-subject to calculate the sample size for a parallel design Nope. You definitely want the total (aka pooled) one. The fact that you observe the PK-response only once in a parallel design does not remove the intra-subject variability. Therefore, what you observe consists of both inter- and intra-subject components. ❝ I'm wrong? Yes. See this post. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2015-05-06 19:50 (3249 d 14:44 ago) @ Helmut Posting: # 14765 Views: 11,915 |
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❝ ❝ ❝ ❝ Liu’s CVs are simply bizarre. Unbelievable that such a paper passed the peer-review. sorry for OT, but this is really, really, really, really.... strange How about a letter to the editor with exactly this question. Something like that should not go unopposed, at least with showing all raw data (really raw)... — Kindest regards, nobody |
Helmut ★★★ Vienna, Austria, 2015-05-06 20:21 (3249 d 14:13 ago) @ nobody Posting: # 14767 Views: 11,867 |
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Hi nobody, ❝ sorry for OT, but this is really, really, really, really.... strange Even with a fancy bioanalytical method we rarely see a CV of <5%. 4.4% of Cmax in a parallel design? Gimme a break. ❝ How about a letter to the editor with exactly this question. Something like that should not go unopposed, at least with showing all raw data (really raw)... Grumpy mood? Do you have a budget to buy the paper? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2015-05-06 20:47 (3249 d 13:47 ago) @ Helmut Posting: # 14768 Views: 11,910 |
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❝ Grumpy mood? Do you have a budget to buy the paper? so to say... little sick of fancy 2% CV studies... I ordered it, may take a few days Edith: ...and sent an email to the first author, see if we can get some details. — Kindest regards, nobody |
Helmut ★★★ Vienna, Austria, 2015-05-06 20:50 (3249 d 13:44 ago) @ nobody Posting: # 14769 Views: 11,860 |
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Hi nobody, ❝ ❝ Grumpy mood? Do you have a budget to buy the paper? ❝ ❝ so to say... little sick of fancy 2% CV studies... Do you know more? ❝ I ordered it, may take a few days Fine. BTW, the database-admin worked on the timeshift. No Δ 13 min anymore – only 1 min. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2015-05-06 20:57 (3249 d 13:37 ago) @ Helmut Posting: # 14770 Views: 11,812 |
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❝ ❝ so to say... little sick of fancy 2% CV studies... ❝ ❝ Do you know more? Not in the public domain... — Kindest regards, nobody |
nobody nothing 2015-05-28 17:53 (3227 d 16:41 ago) @ Helmut Posting: # 14872 Views: 11,355 |
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❝ Even in a fancy bioanalytic method we rarely see a CV of <5%. 4.4% of Cmax in a parallel design? Gimme a break. OT, but slightly on topic, maybe, at least a little bit: http://www.sciencemag.org/content/342/6154/60.full — Kindest regards, nobody |
Helmut ★★★ Vienna, Austria, 2015-05-28 18:00 (3227 d 16:34 ago) @ nobody Posting: # 14873 Views: 11,315 |
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Hi nobody, ❝ OT, but slightly on topic, maybe, at least a little bit: ❝ ❝ http://www.sciencemag.org/content/342/6154/60.full Yep. See also this post and linked references. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
nobody nothing 2015-05-28 18:10 (3227 d 16:24 ago) @ Helmut Posting: # 14874 Views: 11,368 |
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❝ ❝ OT, but slightly on topic, maybe, at least a little bit: ❝ ❝ ❝ ❝ http://www.sciencemag.org/content/342/6154/60.full ❝ ❝ Yep. See also this post and linked references. ... I'm obviously ALWAYS second in this forum... Do I spent to much time elsewhere? — Kindest regards, nobody |