mmw
☆    

India,
2015-02-18 11:10
(3326 d 15:42 ago)

Posting: # 14454
Views: 5,279
 

 Cτss in Phoenix/WinNonlin 6.3 [Software]

Dear All,

I need to report pk parameter Cτss for one of the steady state bioequivalence study. Could we calculate the pk parameter Cτss in Phoenix WinNonlin version 6.3? Cτss is the concentration at the end of the dosing interval at steady state. Could we use Clast = Cτss; as Clast is available in current version software?

Thanks

MMW


Edit: Subject lines changed. [Helmut]
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2015-02-18 13:48
(3326 d 13:05 ago)

@ mmw
Posting: # 14456
Views: 4,339
 

 Estimated Cτss

Hi MMW,

❝ Could we calculate the pk parameter Cτss in Phoenix WinNonlin version 6.3?


If you have reliable estimates (≥3 data points) of λz, yes. See this presentation (slides 16–19). Easy to implement the formula(s) with a few custom transformations In PHX/WNL. Does not only help to cor­rect for deviations from the planned sampling schedule but also – more importantly – to deal with missing values.

❝ Could we use Clast = Cτss; as Clast is available in current version software?


I would do so only as a last resort if the option above is not possible.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
mmw
☆    

India,
2015-02-19 06:35
(3325 d 20:17 ago)

@ Helmut
Posting: # 14458
Views: 4,152
 

 Estimated Cτss

Dear Sir,

Thank you

MMW
UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
69 visitors (0 registered, 69 guests [including 5 identified bots]).
Forum time: 02:53 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5