ElMaestro ★★★ Denmark, 2015-01-23 11:48 (3353 d 01:17 ago) Posting: # 14315 Views: 4,680 |
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Hi all, I am trying to figure out if we can say anything general about the sigma (let's call it s) we get from a 222BE study versus the individual treatment within-sigmas we get from a 224-study (sT and sR). My guess is that the expected value of s will fall in between sT and sR regardless of the magnitude of the fixed treatment effects, but I have no real idea if that holds true. Another way of saying it is that in a simulation experiment s will be in between sT and sR for infinitely big sample sizes. I am probably wrong, though? I am saying this not because I have a mathematical proof but rather because I generally tend to screw up badly when I try to use my sad excuse for a brain. Any insight here? Many thanks in advance. — Pass or fail! ElMaestro |
Helmut ★★★ Vienna, Austria, 2015-01-23 13:52 (3352 d 23:13 ago) @ ElMaestro Posting: # 14317 Views: 3,846 |
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Hi ElMaestro, ❝ My guess is that the expected value of s will fall in between sT and sR regardless of the magnitude of the fixed treatment effects, but I have no real idea if that holds true. Another way of saying it is that in a simulation experiment s will be in between sT and sR for infinitely big sample sizes. Reasonable. Maybe some insights from this one? Chow S-C, Tse S-K. A Related Problem in Bioavailability/Bioequivalence Studies — Estimation of the Intrasubject Variability With a Common CV. Biometr. J. 1990;32(5):597–607. doi 10.1002/bimj.4710320511 — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |