ElMaestro
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Denmark,
2015-01-23 11:48
(3353 d 01:17 ago)

Posting: # 14315
Views: 4,680
 

 Intrasubject variablity, 222BE vs 224BE [General Sta­tis­tics]

Hi all,

I am trying to figure out if we can say anything general about the sigma (let's call it s) we get from a 222BE study versus the individual treatment within-sigmas we get from a 224-study (sT and sR).

My guess is that the expected value of s will fall in between sT and sR regardless of the magnitude of the fixed treatment effects, but I have no real idea if that holds true. Another way of saying it is that in a simulation experiment s will be in between sT and sR for infinitely big sample sizes.

I am probably wrong, though? I am saying this not because I have a mathematical proof but rather because I generally tend to screw up badly when I try to use my sad excuse for a brain.

Any insight here? Many thanks in advance.

Pass or fail!
ElMaestro
Helmut
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Vienna, Austria,
2015-01-23 13:52
(3352 d 23:13 ago)

@ ElMaestro
Posting: # 14317
Views: 3,846
 

 Intrasubject variablity, 222BE vs 224BE

Hi ElMaestro,

❝ My guess is that the expected value of s will fall in between sT and sR regardless of the magnitude of the fixed treatment effects, but I have no real idea if that holds true. Another way of saying it is that in a simulation experiment s will be in between sT and sR for infinitely big sample sizes.


Reasonable. Maybe some insights from this one?

Chow S-C, Tse S-K. A Related Problem in Bioavailability/Bioequivalence Studies — Estimation of the Intrasubject Vari­­abi­lity With a Common CV. Biometr. J. 1990;32(5):597–607. doi 10.1002/bimj.4710320511


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