Snigdhasantra
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2007-11-11 16:37
(5981 d 21:47 ago)

Posting: # 1294
Views: 4,697
 

 Non-parametric tests [Power / Sample Size]

Hi..
I am a student and so, if my question sounds no-technical or stupid, kindly understand... I would like to know if we can calculate sample size in case of a study in which only non-parametric tests (chi square test and Z test) will be applied.
Helmut
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2007-11-11 18:59
(5981 d 19:25 ago)

@ Snigdhasantra
Posting: # 1295
Views: 3,783
 

 Non-parametric tests

Dear Snigdhasantra!

❝ I would like to know if we can calculate sample size in case of a study in which only non-parametric tests (chi square test and Z test) will be applied.


In the context of bioequivalence, which kind of PK metric are you testing?
The Z test is parametric (based on the normal distribution).
For sample size estimation of nonparametric tests you have two options:
  • applying asymptotic normal approximations, or
  • bootstrapping.
For details see
Chow, S-C, Shao J, Wang H. Sample Size Calculations In Clinical Research. Marcel Dekker, New York pp 277-292 (2003)

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