sunny
☆    

2014-04-16 00:18
(3634 d 20:25 ago)

Posting: # 12844
Views: 3,975
 

 BE Trial Simulation in Phoenix [Software]

Dear all,

I am a beginner in this field and this site is great to learn!

I tried to use Phoenix to simulate BE trials to evaluate the BE of two formulations. My Phoenix does have NLME package, but I don't know how to enter the trial design feature into the simulation mode. Any help will be greatly appreciated. Also, after simulating 100 trials (with 24 subjects for each trial), is there an easy to send all those trials to Pheonix for NCA analysis? Manually sending one trial after one sounds a little scaring:confused:

Thanks for your time and help in advance;-)

Sunny
jag009
★★★

NJ,
2014-04-21 17:19
(3629 d 03:24 ago)

@ sunny
Posting: # 12867
Views: 3,217
 

 BE Trial Simulation in Phoenix

Hi Sunny,

❝ I tried to use Phoenix to simulate BE trials to evaluate the BE of two formulations. My Phoenix does have NLME package, but I don't know how to enter the trial design feature into the simulation mode. Any help will be greatly appreciated. Also, after simulating 100 trials (with 24 subjects for each trial), is there an easy to send all those trials to Pheonix for NCA analysis? Manually sending one trial after one sounds a little scaring:confused:


Are you using Phoenix itself to simulate the trials (I think one module has that capability?) or you run your trials and then import the data into Phoenix?

John
SDavis
★★  
Homepage
UK,
2014-04-24 16:25
(3626 d 04:18 ago)

@ sunny
Posting: # 12888
Views: 3,238
 

 BE Trial Simulation in Phoenix

Sunny,
If you have indeed simulated the trials in Phoenix then you could in fact request the NCA 'end points' within the same PML e.g. if you want AUC_t1 to t2 you can add an ODE to the model and capture the value at t2 in a table statement; e.g.

#deriv(AUCt = (t>t1)*(t<t2)*C)
deriv(AUCt = (t>0)*(t<999)*C)

see this post here;

http://www.pharsight.com/extranet/index.php?option=com_kunena&Itemid=55&func=view&catid=40&id=1359&limit=6&limitstart=6#1716

You could also post your question and project there which would probably give you some tips from our own consultants as well as other users.

Simon

Simon
Senior Scientific Trainer, Certara™
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