Bioequivalence and Bioavailability Forum

Dear Shankar / Imran!

❝ We are planning biostudy on dispersible tablet, in this we are going to

❝ compare Test formulation (dispersible tablet) with reference formulation

❝ (oral solution). Test formulation will be dispersed in 30 ml of water and

❝ Reference formulation will be a 25 ml solution.

May I assume you will adminster both formulations (dispersion/solution) from a small cup?

❝ My question is how much volume of water should be administered with Test

❝ or Reference Formulation at the time of dosing, ie, either 240 ml or

❝ less.

Try to follow the administration you have planned to be stated in the SPC / the product's labeling.
Whatever volume you are aiming at, this volume should be the total during administration in the study. If you administer the dispersion from a small cup, you should rinse the cup a least once with a defined amount of water (some particles show nasty adhesion).
If you want to go with 240 ml total, fine:
test: 30 ml dispersion + 30 ml rinse + 180 ml water
ref.: 25 ml solution + 25 ml rinse + 190 ml water