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Alex ☆ Austria, 2012-02-21 13:57 (4885 d 08:17 ago) Posting: # 8147 Views: 4,316 |
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Dear All! The whole PK/PD issue is quite new to me due to the fact that I just graduated from university and biostatistics is a very small part of the curriculum (if it is a part of it at all). Since absolute bioavailability is defined as the dose-adjusted ratio of the geometric mean of AUCs following non-intravenous administration and the geometric mean of AUCs following intravenous bolus or infusion administration, is it valid to draw the conclusion of expecting identical/similar AUCs, whether following intravenous bolus or infusion administration? Best wishes & thx, Alex |
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Helmut ★★★   Vienna, Austria, 2012-02-21 15:02 (4885 d 07:12 ago) @ Alex Posting: # 8148 Views: 3,477 |
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Dear Alex! ❝ […] is it valid to draw the conclusion of expecting identical/similar AUCs, whether following intravenous bolus or infusion administration? Generally yes. Only if the elimination is mainly by metabolization you may see in some (rare) cases after a – reasonably slow – infusion higher AUCs than after a fast bolus. This effect is caused by saturation of enzymes (early/high concentrations of the drug exceeding the capacity). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Alex ☆ Austria, 2012-02-21 15:29 (4885 d 06:45 ago) @ Helmut Posting: # 8149 Views: 3,422 |
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Thx a lot for your fast reply! |
Ing. Helmut Schütz