graveendranath
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2009-12-08 12:01
(5690 d 09:54 ago)

Posting: # 4443
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 Formula for Normalized Cmax [PK / PD]

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Dear Helmut

Could you please explain how to calculate Normalized Cmax?

Edit: Category changed. [Helmut]
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Raveendranath
 
Helmut
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2009-12-08 14:13
(5690 d 07:42 ago)

@ graveendranath
Posting: # 4445
Views: 5,330
 

 Normalized Cmax

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Dear Raveendranath!

Cmax/AUC
See also this post.

References:
  • R Schall and HG Luus
    Comparison of absorption rates in bioequivalence studies of immediate release drug formulations
    Int J Clin Pharm Ther Toxicol 30(5), 153-159 (1992)
  • Endrényi L and W Yan
    Variation of Cmax and Cmax/AUC in investigations of bioequivalence
    Int J Clin Pharm The. Toxicol 31/4, 184-189 (1993)
  • Midha KK, Hubbard JW, Rawson MJ, and L Gavalas
    The application of partial areas in the assessment of rate and extent of absorption in bioequivalence studies of conventional release products: Experimental evidence
    Eur J Pharm Sci 2, 351-363 (1994)
  • Schall R, Luus HG and VW Steinijans
    Choice of characteristics and their bioequivalence ranges for the comparison of absorption rates of immediate-release drug formulations
    Int J Clin Pharm Ther 32(7), 323-328 (1994)
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