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jag009 ★★★ NJ, 2020-04-14 23:33 (1907 d 19:46 ago) Posting: # 21330 Views: 5,475 |
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Hi everyone, I once heard that IM injection tends to yield higher variability in PK, is that true? Relative to IV. Thanks John |
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ElMaestro ★★★ Denmark, 2020-04-15 00:02 (1907 d 19:17 ago) @ jag009 Posting: # 21331 Views: 3,281 |
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Hi John, ❝ I once heard that IM injection tends to yield higher variability in PK, is that true? Relative to IV. I think that's true by some margin, usually. One joker is that IM is not IM. Quite a few IM injections end up being SC in part or in whole. — Pass or fail! ElMaestro |
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Helmut ★★★   Vienna, Austria, 2020-04-15 00:56 (1907 d 18:22 ago) @ jag009 Posting: # 21332 Views: 3,273 |
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Hi John, ❝ […] IM injection tends to yield higher variability in PK, is that true? Relative to IV. By “definition”? As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug). Sorry for the long sentence. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2020-04-21 23:00 (1900 d 20:18 ago) @ Helmut Posting: # 21340 Views: 3,127 |
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Thank you both :) |
Ing. Helmut Schütz