Bioequivalence and Bioavailability Forum

Subject	Author	posted	Replies	last R.	Views
Concentration Statistics - BQL substitution Concentration Statistics - BQL substitution Concentration Statistics - BQL substitution Data imputation Concentration Statistics - BQL substitution Concentration Statistics - BQL substitution Concentration Statistics - BQL substitution BQL in BE and PK modeling Concentration Statistics - BQL substitution Roger again	SaraCHenriques	2020-07-01 14:37	9	2020-07-08 12:03	1,538
higher order crossover methodology All dosed subjects have to be analyzed All dosed subjects have to be analyzed higher order crossover methodology higher order crossover methodology higher order crossover methodology Fed (IBD) → fasting Fed (IBD) → fasting	sweiner	2020-06-30 01:07	7	2020-07-07 03:00	1,502
Statistical independence, what is it? I mean really, what is it?? Die don’t remember the last roll. Really. Die don’t remember the last roll. Really. Die don’t remember the last roll. Really. Still none the wiser You’ve lost me now. Worded differently Still not sure what you are aiming at… Still not sure what you are aiming at… Confuse-a-Cat Confuse-a-Cat Confuse-a-Cat pseudorandom and linear independence Statistical independence, what is it? I mean really, what is it?? Statistical independence, what is it? I mean really, what is it?? Statistical independence, what is it? I mean really, what is it??	ElMaestro	2020-06-27 21:35	15	2020-07-01 10:07	2,326
truncation issues EMA: AUC72 for all IR products EMA: AUC72 for all IR products	Loky do	2020-06-24 03:23	2	2020-06-24 12:08	1,214
protocol amendment that may trigger Group effect test protocol amendment that may trigger Group effect test	Silke	2020-03-24 08:52	1	2020-03-24 09:07	1,359
ANOVA MODEL No random effects in ANOVA No random effects in ANOVA	abhimanyu	2020-02-04 05:31	2	2020-02-05 12:47	1,674
Group by sequence interaction Group by sequence interaction, an urban myth? pristine, genuine, holy, magnificent, inexplicable beautiful variation I love your subject line! Group effect, did you miss it? Group effect, did you miss it? Group effect: the endless story Group effect: the endless river Group effect: the endless river replicateBE solution with interactions replicateBE solution with interactions datasets issues datasets datasets lmer / lme What do you mean exactly? What do you mean exactly? ANOVA acc. to GL	Mutasim	2019-08-07 13:16	17	2019-12-30 12:32	4,463
On CI calculation, untransformed metrics Fieller’s (‘fiducial’) confidence interval Fieller’s (‘fiducial’) confidence interval Fieller’s (‘fiducial’) confidence interval Fieller’s (‘fiducial’) confidence interval power.TOST with logscale=FALSE On CI calculation, untransformed metrics	ElMaestro	2019-11-29 03:40	6	2019-11-30 14:01	1,764
Power Model Power Model	Vivek Chaudhari	2019-11-27 07:12	1	2019-11-27 14:35	1,317
What is the largest α (Alpha) & β (Beta) allowed by FDA? What do you want to achieve? I'm seeking to understand the math behind our current regulation Some answers Wow! Amazing answers! More answers Wow! More amazing answers! Books & intersection-union My progress on IUT so far Update: Counterexamples	victor	2019-11-16 21:57	9	2019-11-23 09:05	3,903
Least square mean calculation for the fully replicate design Very, very strange! Very, very strange! Very, very strange! Very, very strange! G matrix Inner workings of REML Even in ANOVA… Even in 2x2... trying to understand emmeans Least square mean calculation for the fully replicate design	Jaimik Patel	2019-10-31 11:19	10	2019-11-03 01:38	2,249
Indirect adjusted comparisons in BE Pragmatic assumptions Indirect adjusted comparisons in BE Indirect adjusted comparisons in BE Indirect adjusted comparisons in BE Indirect adjusted comparisons in BE Indirect adjusted comparisons in BE	Helmut	2019-07-21 15:20	6	2019-07-22 18:38	2,468
biostatistics	Aida hassan	2019-06-13 15:29	0		1,472
SAS and R (?) for variability comparison (FDA NTID Guidance) SAS and R (?) for variability comparison (FDA NTID Guidance) SAS and R (?) for variability comparison (FDA NTID Guidance) Missings Missings LaTeX, MathML, PNGs OT: LaTeX, MathML, PNGs OT: LaTeX, MathML, PNGs Quantiles of the F-distribution Quantiles of the F-distribution What's wrong with this picture? Suggestion Suggestion OT: The Hadleyverse Another suggestion for a R-solution Wow – another gem from the master! Another suggestion for a R-solution Another R-solution @Shuanghe: Outdated URL SAS and R (?) for variability comparison (FDA NTID Guidance) SAS and R (?) for variability comparison (FDA NTID Guidance)	Shuanghe	2015-09-25 18:48	20	2019-05-21 11:36	23,738
Why BE testing use 90 CI Why BE testing use 90 CI Why BE testing use 90 CI one-sided / two-sided one-sided / two-sided one-sided / two-sided	akash	2019-02-23 08:39	5	2019-03-04 11:25	3,024