Bioequivalence and Bioavailability Forum

Subject	Author	posted	R’s	last reply	V’s
long half life drug bioequivalence study design long half life drug bioequivalence study design Truncted AUC, low variability	ssussu	2017-08-16 11:45	2	2017-08-16 14:18	74
Paliperidone palmitate IM model effects Paliperidone palmitate study design Paliperidone palmitate study design Paliperidone palmitate study design Paliperidone palmitate study design	M.tareq	2017-06-27 23:46	4	2017-08-07 21:48	1,085
General BE topics General BE topics General BE topics General BE topics General BE topics forced BE? forced BE? forced BE? forced BE? forced BE? forced BE? forced BE? forced BE?	VSL	2017-06-05 20:34	12	2017-08-07 15:58	1,493
Why to dose 2 tablets of 200 mg tablets of Amiodarone in BE studies	KK	2017-05-26 11:09	0		447
More samples – less variability (for Cmax)? More samples – less variability (for Cmax) Sample volume Sample volume Sample volume More samples – less variability (for Cmax)	nobody	2017-05-23 09:07	5	2017-05-23 19:00	843
PK of new molecules PK of new molecules PK of new molecules PK of new molecules PK of new molecules	BE-proff	2017-04-18 06:25	4	2017-04-25 09:17	951
How to calculate this assumption...if AUCt is at least 80% of AUC∞... How to calculate this assumption...if AUCt is at least 80% of AUC∞... How to calculate this assumption...if AUCt is at least 80% of AUC∞... How to calculate this assumption...if AUCt is at least 80% of AUC∞... How to calculate this assumption...if AUCt is at least 80% of AUC∞... How to calculate this assumption...if AUCt is at least 80% of AUC∞...	javier	2017-03-28 23:21	5	2017-03-30 22:44	928
Fed VS Fast state in BE studies Fed VS Fast state in BE studies PPIs sometimes highly variable even in fasted state PPIs sometimes highly variable even in fasted state Refuse-to-Receive Standards Refuse-to-Receive Standards Refuse-to-Receive Standards	M.tareq	2017-02-26 09:34	6	2017-03-17 16:27	1,470
Replicate designs Replicate designs: Pros & Cons Replicate designs: Pros & Cons Replicate designs: Pros & Cons Partial replicate design & ABE for the FDA Partial replicate design & ABE for the FDA Partial replicate design & ABE for the FDA Partial replicate design & ABE for the FDA Partial replicate design & ABE for the FDA	VSL	2017-01-31 06:47	8	2017-03-06 17:49	2,145
Replicate or not? Replicate or not? Replicate or not? Replicate or not? Replicate or not? Replicate or not? Replicate or not? Can of worms Replicate or not? Replicate or not?	Mikkabel	2017-02-16 12:18	9	2017-02-16 18:05	1,514
The Rubbish Gambit	ElMaestro	2017-01-01 22:47	0		882
Significant period effect Significant period effect period x sequence period x sequence	jag009	2016-12-20 04:48	3	2016-12-21 22:21	1,428
Food PH and fed study bioequivalence Food PH and fed study bioequivalence	Tina	2016-12-12 11:40	1	2016-12-12 11:59	1,099
Any post about difference between 4x4 and 4x2 in bioequivalence studies? Not more than 2 sequences in full replicates Not more than 2 sequences in full replicates Only RR is used Not more than 2 sequences in full replicates	Mauricio Sampaio	2016-11-03 18:54	4	2016-11-11 20:52	2,546
Design HVDP extra-reference design extra-reference design extra-reference design extra-reference design Design HVDP	Yura	2016-11-09 09:10	5	2016-11-10 13:49	2,811
Ambroxol Sustained Release 75 mg Ambroxol Sustained Release 75 mg	MaggieSantos	2016-10-28 18:16	1	2016-11-02 10:51	1,303