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Register# of sequence for 5-tmt-5period design [Design Issues]
Dear John,
what do you mean with five-way
.
Assume you mean a cross-over study with 5 treatments in 5 periods.
If you want to go with a Williams design you need 10 sequences.
If you don't need the extra-balance of a Williams design, and IMHO you don't need it if you have no carry-over term in your evaluation model (specifically "first order" carry-over which is totally flawed, see 1)) you can go with 5 sequences (5x5 Latin square).
Search for "Williams design" to find a lot of discussions we had here in the forum.
(1)S. Senn
Cross-over Trials in Clinical Research
John Wiley & Sons, Chichester, pp162-163 (2nd ed. 2002)
Chapter 10
❝ If I want to run a 5-way crossover study, would 5-sequence be sufficient or I need to go 10? Crazy stuff...
what do you mean with five-way
.Assume you mean a cross-over study with 5 treatments in 5 periods.
If you want to go with a Williams design you need 10 sequences.
If you don't need the extra-balance of a Williams design, and IMHO you don't need it if you have no carry-over term in your evaluation model (specifically "first order" carry-over which is totally flawed, see 1)) you can go with 5 sequences (5x5 Latin square).
Search for "Williams design" to find a lot of discussions we had here in the forum.
(1)S. Senn
Cross-over Trials in Clinical Research
John Wiley & Sons, Chichester, pp162-163 (2nd ed. 2002)
Chapter 10
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- # of sequence for higher order crossover design jag009 2013-01-28 16:01 [Design Issues]
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- # of sequence for 5-tmt-5period designd_labes 2013-01-28 16:37
- # of sequence for 5-tmt-5period design jag009 2013-01-28 17:18
- # of sequence for 5-tmt-5period design jag009 2013-01-29 15:12
- Simulate 5x5x5 cross-over? d_labes 2013-01-29 15:28
- Simulate 5x5x5 cross-over? jag009 2013-01-29 16:04
- Simulate a full replicate study d_labes 2013-01-29 16:52
- Simulate a full replicate study jag009 2013-01-29 17:00
- Simulate 5x5x5 cross-over? ElMaestro 2013-01-30 10:10
- Simulate 5x5x5 cross-over? jag009 2013-01-31 15:31
- Simulate 5x5x5 cross-over? ElMaestro 2013-01-31 17:13
- Simulate 5x5x5 cross-over? jag009 2013-02-01 15:33
- Simulate 5x5x5 cross-over? ElMaestro 2013-02-01 16:50
- Simulate 5x5x5 cross-over? jag009 2013-02-01 20:36
- Simulate 5x5x5 cross-over? ElMaestro 2013-02-02 02:21
- Simulate 5x5x5 cross-over? jag009 2013-02-04 15:06
- Simulate 5x5x5 cross-over? ElMaestro 2013-02-02 02:21
- Sokme? d_labes 2013-02-04 09:05
- Some ElMaestro 2013-02-04 11:16
- Simulate 5x5x5 cross-over? jag009 2013-02-01 20:36
- Simulate 5x5x5 cross-over? ElMaestro 2013-02-01 16:50
- Simulate 5x5x5 cross-over? jag009 2013-02-01 15:33
- Simulate 5x5x5 cross-over? ElMaestro 2013-01-31 17:13
- Simulate 5x5x5 cross-over? jag009 2013-01-31 15:31
- Simulate a full replicate study d_labes 2013-01-29 16:52
- Simulate 5x5x5 cross-over? jag009 2013-01-29 16:04
- Simulate 5x5x5 cross-over? d_labes 2013-01-29 15:28
- # of sequence for 5-tmt-5period designd_labes 2013-01-28 16:37
Ing. Helmut Schütz