Bioequivalence and Bioavailability Forum

TTT method [NCA / SHAM]

posted by hiren379 – India, 2012-07-11 14:53 (5081 d 08:12 ago) – Posting: # 8930
Views: 29,685

❝ Please avoid SMS spelling in your messages on this forum.

sorry as I am new to this forum

❝ Let me replace multicompartmental with multiphasic, then ?

Then how can you assume monophasic when calculating Kel for extra vascular drug administration. May be when you are calculating Kel for a tablet distribution is still on??

❝ 1. F*** R2

Strongly with you for this

❝ 2. I don't assume instantaneous distribution or monophasic elimination without looking at the PK profiles for each subject.

❝ (Also look at Helmut's first message in this same thread).

I also believe in this

So I think conclusion is that manual selection coupled with statistical method is best irrespective of dosage form....
Is it OK?

Now if I am using this + I know that my drug is having instantaneous distribution then still I should go for manual linearity finding. Will it not be bias???

Complete thread:

• Methods for calculation of half lives d_labes 2008-02-01 14:58 [NCA / SHAM] 
  • Methods for calculation of half lives Helmut 2008-02-01 16:59
    • Methods for calculation of half lives Ohlbe 2008-02-02 23:00
      • Minimum AIC?! Helmut 2008-02-03 13:49
        • G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
    • Methods for calculation of half lives d_labes 2008-02-04 16:43
      • MAIC and beyond... Helmut 2008-02-04 17:49
  • TTT method Helmut 2008-05-10 13:56
    • TTT method d_labes 2008-05-16 09:12
      • TTT method Helmut 2008-05-16 17:21
        • TTT method d_labes 2008-05-23 15:43
          • TTT method hiren379 2012-07-11 11:11
            • TTT method Ohlbe 2012-07-11 11:37
              • TTT method hiren379 2012-07-11 11:44
                • TTT method Ohlbe 2012-07-11 12:16
                  • TTT methodhiren379 2012-07-11 12:53
                    • Eyeball-PK Helmut 2012-07-11 14:37
                      • Eyeball-PK hiren379 2012-07-11 15:28
                        • Eyeball-PK Helmut 2012-07-11 15:47
                          • Eyeball-PK hiren379 2012-07-11 16:24