Bioequivalence and Bioavailability Forum

TTT method [NCA / SHAM]

posted by hiren379 – India, 2012-07-11 13:44 (5081 d 10:13 ago) – Posting: # 8928
Views: 29,631

❝ No: you may have a distribution phase first. Infusion does not mean monocompartmental PK. You still need to only consider the terminal elimination phase.

Thanks but will the same work for Non compartmental model also? And if you are so worried about including the time of distribution then the postulate of instantaneous distribution is violated for using Non compartment model.


And if u are assuming instantaneous distribution then one must take all time points after completion of infusion to avoid bias created by statistics of R2

And I knew that distribution will come into play and hence I have mentioned slow infusion.

Complete thread:

• Methods for calculation of half lives d_labes 2008-02-01 14:58 [NCA / SHAM] 
  • Methods for calculation of half lives Helmut 2008-02-01 16:59
    • Methods for calculation of half lives Ohlbe 2008-02-02 23:00
      • Minimum AIC?! Helmut 2008-02-03 13:49
        • G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
    • Methods for calculation of half lives d_labes 2008-02-04 16:43
      • MAIC and beyond... Helmut 2008-02-04 17:49
  • TTT method Helmut 2008-05-10 13:56
    • TTT method d_labes 2008-05-16 09:12
      • TTT method Helmut 2008-05-16 17:21
        • TTT method d_labes 2008-05-23 15:43
          • TTT method hiren379 2012-07-11 11:11
            • TTT method Ohlbe 2012-07-11 11:37
              • TTT methodhiren379 2012-07-11 11:44
                • TTT method Ohlbe 2012-07-11 12:16
                  • TTT method hiren379 2012-07-11 12:53
                    • Eyeball-PK Helmut 2012-07-11 14:37
                      • Eyeball-PK hiren379 2012-07-11 15:28
                        • Eyeball-PK Helmut 2012-07-11 15:47
                          • Eyeball-PK hiren379 2012-07-11 16:24