Bioequivalence and Bioavailability Forum • TTT method

TTT method [NCA / SHAM]

posted by Ohlbe – France, 2012-07-11 13:37 (5081 d 08:25 ago) – Posting: # 8927
Views: 29,526

Dear Hiren,

❝ Once the infusion is over pharmacologically the only phase running in human body is elimination of drug as absorption is completed (end of infusion). Then shouldn't we consider all the time points after the end of infusion time as here in this case we are sure that after what particular time only elimination happens.

No: you may have a distribution phase first. Infusion does not mean monocompartmental PK. You still need to only consider the terminal elimination phase.

Regards
Ohlbe

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Regards
Ohlbe

Complete thread:

Methods for calculation of half lives d_labes 2008-02-01 14:58 [NCA / SHAM]
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    - MAIC and beyond... Helmut 2008-02-04 17:49
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        TTT method hiren379 2012-07-11 11:11
        
        TTT methodOhlbe 2012-07-11 11:37
        
        TTT method hiren379 2012-07-11 11:44
        
        TTT method Ohlbe 2012-07-11 12:16
        
        TTT method hiren379 2012-07-11 12:53
        
        Eyeball-PK Helmut 2012-07-11 14:37
        
        Eyeball-PK hiren379 2012-07-11 15:28
        
        Eyeball-PK Helmut 2012-07-11 15:47
        
        Eyeball-PK hiren379 2012-07-11 16:24