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A few clarifications: this is data from healthy volunteers aged 18-45y who received a single oral dose. The values are arithmetic mean. We wish to estimate PK parameters. The LLOQ is 1.96
Queries:
1. It was recommended in the Forum to use the last 4 time points for kel. Do we take the last four time points for each or look at the graph of each volunteer and decide (4 points for some and 3 or 5 for others)?
2. The last time point is 72 hours and there are several volunteers in whom no drug was detected. Do we write zero and include that into calculations or we do not take that time point at all for that particular volunteer ?
thanks
Queries:
1. It was recommended in the Forum to use the last 4 time points for kel. Do we take the last four time points for each or look at the graph of each volunteer and decide (4 points for some and 3 or 5 for others)?
2. The last time point is 72 hours and there are several volunteers in whom no drug was detected. Do we write zero and include that into calculations or we do not take that time point at all for that particular volunteer ?
thanks
Complete thread:
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 10:59 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
- which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
- Wetware required Helmut 2012-06-12 15:59
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-13 08:58
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Wetware required jag009 2012-06-12 17:38
- Wetware required Helmut 2012-06-12 19:50
- Wetware required jag009 2012-06-12 17:40
- Wetware required Helmut 2012-06-12 18:23
- Wetware requiredSamir Malhotra 2012-06-13 09:39
- Fit individuals; ignore BQLs Helmut 2012-06-13 20:33
- Wetware requiredSamir Malhotra 2012-06-13 09:39
- Wetware required Helmut 2012-06-12 18:23
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Wetware required Helmut 2012-06-12 15:59
- which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
Ing. Helmut Schütz