Bioequivalence and Bioavailability Forum

Geometric, arithmetic, median ... ? [NCA / SHAM]

posted by Helmut  – Vienna, Austria, 2012-06-13 10:58 (5109 d 17:31 ago) – Posting: # 8723
Views: 15,036

Dear Detlew!

❝ ❝ But on the other hand: Is this really important? We don’t base any conclusions on curves; they are simple illustrations ...

❝

❝ Beside curves with "nasty Lag-times & values <LLOQ" it seldom makes a difference.

Agree.

❝ ❝ Who never was confronted with a question like “I measured the Cmax of test and reference from the plot on page 4 as 65 and 70; so why do you state on page 3 the PE is only 88%?” ...

❝

❝ I definitely was. Frequently from 'experienced ...' (fill in what fits your need) .

Will meet ElMaestro today. Will discuss and come up with a list to fill in the gap.

---

Edit: Sorry, cannot publish that.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

• which time points to use for calculation of kel Samir Malhotra 2012-06-12 10:59 [NCA / SHAM] 
  • which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
    • which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
      • which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
      • which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
        • which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
          • Wetware required Helmut 2012-06-12 15:59
            • Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
              • Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
                • Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
                  • Geometric, arithmetic, median ... ?Helmut 2012-06-13 08:58
            • Wetware required jag009 2012-06-12 17:38
              • Wetware required Helmut 2012-06-12 19:50
            • Wetware required jag009 2012-06-12 17:40
              • Wetware required Helmut 2012-06-12 18:23
                • Wetware required Samir Malhotra 2012-06-13 09:39
                  • Fit individuals; ignore BQLs Helmut 2012-06-13 20:33