Bioequivalence and Bioavailability Forum

Geometric, arithmetic, median ... ? [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2012-06-13 10:53 (5109 d 17:41 ago) – Posting: # 8722
Views: 15,094

Dear Helmut!

❝ But on the other hand: Is this really important? We don’t base any conclusions on curves; they are simple illustrations ...

That's "des Pudels Kern" (J.W. Goethe, "Faust, part I").
Beside curves with "nasty Lag-times & values <LLOQ" it seldom makes a difference.

❝ Who never was confronted with a question like “I measured the Cmax of test and reference from the plot on page 4 as 65 and 70; so why do you state on page 3 the PE is only 88%?” ...

I definitely was. Frequently from 'experienced ...' (fill in what fits your need) .

Complete thread:

• which time points to use for calculation of kel Samir Malhotra 2012-06-12 10:59 [NCA / SHAM] 
  • which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
    • which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
      • which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
      • which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
        • which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
          • Wetware required Helmut 2012-06-12 15:59
            • Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
              • Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
                • Geometric, arithmetic, median ... ?d_labes 2012-06-13 08:53
                  • Geometric, arithmetic, median ... ? Helmut 2012-06-13 08:58
            • Wetware required jag009 2012-06-12 17:38
              • Wetware required Helmut 2012-06-12 19:50
            • Wetware required jag009 2012-06-12 17:40
              • Wetware required Helmut 2012-06-12 18:23
                • Wetware required Samir Malhotra 2012-06-13 09:39
                  • Fit individuals; ignore BQLs Helmut 2012-06-13 20:33