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Registerwhich time points to use for calculation of kel [NCA / SHAM]
Hi Samir,
I am sorry, I might have misunderstood you then. In BE you generally to go through all individual plots and derive an elimination constant. But if you are working with the overall mean plot here then you might not be doing BE but rather characterising a new chemical entity?
If so, then I guess you can consider the grand mean, pop PK as well as individual plots.
Perhaps you can briefly explain the overall purpose of the trial?
❝ this data is mean of 16 volunteers, do I need to check the plot for each volunteer or the plot of mean concentration. In the earlier posts it has been mentioned that looking at individual plots is not correct. What would be your opinion?
I am sorry, I might have misunderstood you then. In BE you generally to go through all individual plots and derive an elimination constant. But if you are working with the overall mean plot here then you might not be doing BE but rather characterising a new chemical entity?
If so, then I guess you can consider the grand mean, pop PK as well as individual plots.
Perhaps you can briefly explain the overall purpose of the trial?
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 10:59 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
- which time points to use for calculation of kelElMaestro 2012-06-12 12:39
- Wetware required Helmut 2012-06-12 15:59
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-13 08:58
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Wetware required jag009 2012-06-12 17:38
- Wetware required Helmut 2012-06-12 19:50
- Wetware required jag009 2012-06-12 17:40
- Wetware required Helmut 2012-06-12 18:23
- Wetware required Samir Malhotra 2012-06-13 09:39
- Fit individuals; ignore BQLs Helmut 2012-06-13 20:33
- Wetware required Samir Malhotra 2012-06-13 09:39
- Wetware required Helmut 2012-06-12 18:23
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Wetware required Helmut 2012-06-12 15:59
- which time points to use for calculation of kelElMaestro 2012-06-12 12:39
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
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