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Registerwhich time points to use for calculation of kel [NCA / SHAM]
Read with interest the discussion and posts of Detlew Labes about the calculation of terminal half life, especially of choosing the linear part.
Please help us in applying that to our real data from 16 volunteers who received a single oral dose of a new (numbered) compound. Which method (ARS, TTT, any other) should be used? And which time points?
![[image]](img/uploaded/image33.jpg)
Please help us in applying that to our real data from 16 volunteers who received a single oral dose of a new (numbered) compound. Which method (ARS, TTT, any other) should be used? And which time points?
Time Mean Concentration
0.5 18.63
0.75 41.24
1.0 78.27
1.5 112.04
2.0 121.33
4.0 85.60
6.0 41.57
8.0 26.64
12.0 15.23
18.0 6.38
24.0 4.67
48.0 2.07
72.0 0.64Complete thread:
- which time points to use for calculation of kelSamir Malhotra 2012-06-12 10:59 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:35
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:59
- which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
- Wetware required Helmut 2012-06-12 15:59
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-13 08:58
- Geometric, arithmetic, median ... ? d_labes 2012-06-13 08:53
- Geometric, arithmetic, median ... ? Helmut 2012-06-12 17:51
- Wetware required jag009 2012-06-12 17:38
- Wetware required Helmut 2012-06-12 19:50
- Wetware required jag009 2012-06-12 17:40
- Wetware required Helmut 2012-06-12 18:23
- Wetware required Samir Malhotra 2012-06-13 09:39
- Fit individuals; ignore BQLs Helmut 2012-06-13 20:33
- Wetware required Samir Malhotra 2012-06-13 09:39
- Wetware required Helmut 2012-06-12 18:23
- Geometric, arithmetic, median ... ? d_labes 2012-06-12 16:28
- Wetware required Helmut 2012-06-12 15:59
- which time points to use for calculation of kel ElMaestro 2012-06-12 12:39
- which time points to use for calculation of kel Samir Malhotra 2012-06-12 11:28
- which time points to use for calculation of kel ElMaestro 2012-06-12 11:16
Ing. Helmut Schütz