Bioequivalence and Bioavailability Forum

Hi everyone,

Could you help me on the following:

Assuming the plasma conc-time profile of a drug follows a extravascular (oral) 1st order 2 compartment model represented by the exponential equation:

Equation A: C(t)=A*exp(-alpha*t)+B*exp(-beta*t)+C*exp(-k01*t), where C = -(A+B).

How do I go about to generate a theoretical bolus IV profile

I assumed the equation to be (by remove the last term from equation A):

Equation B: C(t)=A*exp(-alpha*t)+B*exp(-beta*t)?

I tried that but the AUC from a equation A did not equal to equation B.

Am I doing something wrong?

Thanks

John