Bioequivalence and Bioavailability Forum

❝ how to measure permeability of drug,

The following methods can be used to determine the permeability of a drug substance from the gastrointestinal tract:
(1) in vivo intestinal perfusion studies in humans;
(2) in vivo or in situ intestinal perfusion studies using suitable animal models;
(3) in vitro permeation studies using excised human or animal intestinal tissues; or
(4) in vitro permeation studies across a monolayer of cultured epithelial cells.