Steady state calculation using WinNonlin [Software]
Dear HS
Thanks for ur mail and valuable suggestion on the issue. I data I want to estimate for SS study is given below.
The step I followed calculation of PK Parameters is as:
PK/PD/NCA Analysis Wizard , noncompartment modeling, select model 200, data variables, dosage regimen and selecting steady state followed by modeling, generation of PK output.
The XL file I have attached, the data processed is excluding trough sample (day1, 5, 6 and 7), should I process trough data and profiling data separately.
As u wrote in ur mail that in WinNonlin %PTF to be calculate manually, but here in my case I calculated all of the primary and secondary parameters (Excel file attached).
I have troubleshooting how the data to be presented in the WinNonline, I tried in all the possible way, but I am not sure about the output.
Primary Efficacy Parameters: Cmin, Cmax, AUC0 - 
Secondary Efficacy Parameters: Tmax, % Fluctuation
Please suggest.
Regards
Dr.Imran Khan
Thanks for ur mail and valuable suggestion on the issue. I data I want to estimate for SS study is given below.
Subject Period Trough sample Profiling till 72.00 hrs
Day 1 Day-5 Day-6 Day-7 Day-7
0.0 hr 0.0 hr 0.0 hr 0.0 hr 1.0 hr
2 2 BLQ 13.344 13.689 12.272 8.427
3 1 BLQ 2.408 2.88 3.299 2.944
4 1 BLQ 6.068 7.562 5.267 4.734
5 1 BLQ 4.711 6.01 6.407 5.082
6 2 BLQ 5.594 5.134 4.733 3.691
7 2 BLQ 4.043 5.055 3.842 3.867
8 1 BLQ 6.104 6.033 6.144 5.251
9 2 BLQ 7.272 8.825 10.937 6.892
10 2 BLQ 2.671 3.53 3.655 2.744
11 1 BLQ 2.238 6.671 3.635 3.092
12 2 BLQ 8.961 4.591 5.078 4.127
13 1 BLQ 9.957 11.607 8.85 7.571
14 2 BLQ 2.596 3.972 2.756 2.696
15 1 BLQ 5.578 5.959 4.593 3.244
16 2 BLQ 4.135 5.602 6.656 5.397
17 1 BLQ 3.339 3.985 2.957 3.241
18 2 BLQ 7.984 6.268 4.776 3.843
19 1 BLQ 5.478 5.781 5.357 4.043
20 2 BLQ 17.672 21.912 24.53 22.566
The step I followed calculation of PK Parameters is as:
PK/PD/NCA Analysis Wizard , noncompartment modeling, select model 200, data variables, dosage regimen and selecting steady state followed by modeling, generation of PK output.
The XL file I have attached, the data processed is excluding trough sample (day1, 5, 6 and 7), should I process trough data and profiling data separately.
As u wrote in ur mail that in WinNonlin %PTF to be calculate manually, but here in my case I calculated all of the primary and secondary parameters (Excel file attached).
I have troubleshooting how the data to be presented in the WinNonline, I tried in all the possible way, but I am not sure about the output.
Primary Efficacy Parameters: Cmin, Cmax, AUC0 - 
Secondary Efficacy Parameters: Tmax, % Fluctuation
Please suggest.
Regards
Dr.Imran Khan
—
Dr.Imran Khan
Dr.Imran Khan
Complete thread:
- Steady state calculation using WinNonlin Imran 2007-06-27 06:02
- Steady state calculation using WinNonlin Helmut 2007-06-27 11:56
- Steady state calculation using WinNonlinImran 2007-06-29 05:13
- Please use the Preview! Jaime_R 2007-06-29 10:29
- Please use the Preview! Imran 2007-06-30 12:50
- no attachments and uploads... Jaime_R 2007-06-30 13:33
- Please use the Preview! Imran 2007-06-30 12:50
- Steady state calculation using WinNonlin Helmut 2007-06-29 21:08
- Steady state calculation using WinNonlin Imran 2007-08-02 13:52
- Steady state calculation using WinNonlin Helmut 2007-08-02 15:07
- Steady state calculation using WinNonlin Imran 2007-08-06 11:48
- Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16
- Exclusion of subjects who are not in SS KR 2009-04-13 14:34
- Exclusion of subjects who are not in SS vixen 2020-04-27 10:10
- Common sense instead of statistics Helmut 2020-04-27 11:45
- Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16
- Steady state calculation using WinNonlin Imran 2007-08-06 11:48
- Steady state calculation using WinNonlin Helmut 2007-08-02 15:07
- Steady state calculation using WinNonlin Imran 2007-08-02 13:52
- Please use the Preview! Jaime_R 2007-06-29 10:29
- Steady state calculation using WinNonlinImran 2007-06-29 05:13
- Steady state calculation using WinNonlin Helmut 2007-06-27 11:56